# In vitro core

> **NIH NIH U19** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $723,182

## Abstract

In Vitro Core
Project Summary
The overarching goal of the Wisconsin Antimicrobial Drug Discovery and Development Center is to
develop therapeutic countermeasures to tackle the antimicrobial resistance crisis. To assist in achieving
that goal, the In Vitro Core will use state-of-the-art acoustic liquid handling robotics to assay the
fractionated extracts and compounds for antibacterial and antifungal activity, toxicity on human primary
cells, and hemolysis of red blood cells. The Core will provide the projects with data from secondary
screens on strains resistant to available antibiotics or a Candida auris strain resistant to all clinically
available antifungals.
Relevance
The In Vitro Core will provide the Center and the three Projects with critical data on the antimicrobial,
antifungal and in vitro toxicity of new compounds so that the Center can develop new, broad spectrum
antimicrobial agents.

## Key facts

- **NIH application ID:** 9868272
- **Project number:** 5U19AI142720-02
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** F. Michael Hoffmann
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $723,182
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9868272

## Citation

> US National Institutes of Health, RePORTER application 9868272, In vitro core (5U19AI142720-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9868272. Licensed CC0.

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