# Preventing Persistent Post-Surgical Pain and Dysfunction in At-Risk Veterans: Effect of a Brief Behavioral Intervention

> **NIH NIH R01** · UNIVERSITY OF IOWA · 2020 · $652,060

## Abstract

Persistent post-surgical pain (PPSP) and impaired functioning are common among patients undergoing
total knee arthroscopy (TKA). Pain that persists beyond the expected period of healing can be devastating to
one's sense of well-being. In fact, pain severity is highly correlated with adverse effects on physical functioning.
Strong and consistent evidence indicates that patients with high anxiety and/or depressive symptoms (distress)
prior to surgery are at risk for PPSP. Veterans are at particularly high risk for post-surgical problems because
80% experience some level of psychological distress prior to surgery and 50% report experiencing pain on a
regular basis. Scheduled surgery is a critical juncture with the healthcare system that provides an important
opportunity to identify and address these issues. Acceptance and Commitment Therapy (ACT) is a trans-
diagnostic and evidence-based treatment for depression, anxiety, and chronic pain. Importantly, ACT has been
effectively implemented in various treatment-delivery formats, including intensive 1-day group workshops.
 This application proposes a multi-site, double-blind, two-arm, parallel, randomized controlled trial
comparing the effects of an ACT intervention to an attention control (AC) intervention in Veterans at-risk for
PPSP following TKA. Veterans with high levels of pain and significant distress prior to TKA will be identified as
“at-risk.” The primary aim of this study is to examine the efficacy of ACT compared to AC on pain and
functioning in at-risk Veterans at 6 weeks, 3 and 6 months post-TKA. The secondary aim is to examine the
effects of ACT, compared to AC, on depressive and anxiety symptoms and on coping skills. Mediation
analyses will be conducted to examine whether changes in depression, anxiety, and coping skills have an
impact on pain and functioning. Finally, we will explore the impact of the current opioid restrictions on the use
of pharmacological and non-pharmacological pain management strategies following TKA. The current proposal
builds on promising results from a R34-funded preliminary study.
 Providing this therapy prior to surgery for people struggling with depressive and anxiety symptoms, for the
purpose of preventing PPSP and impaired functioning following surgery, is innovative. It has the potential to
change clinical practice from a focus on management of postoperative pain to prevention of chronic pain in at-
risk individuals. This project incorporates an interdisciplinary approach to the care of Veterans that attends to
major risk factors of postoperative sequelae that significantly impact Veterans' quality of life and healthcare
utilization. Thus, it has the potential to translate what is known about effective treatments of distress and
chronic pain to prevent poor surgical outcomes. The format is brief and innovative, offering potential for optimal
treatment adherence, participant acceptability, and broad deployment to practice settings. Finally, this more
conc...

## Key facts

- **NIH application ID:** 9869049
- **Project number:** 5R01NR017610-02
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Lilian Nazar Dindo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $652,060
- **Award type:** 5
- **Project period:** 2019-02-08 → 2023-11-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9869049

## Citation

> US National Institutes of Health, RePORTER application 9869049, Preventing Persistent Post-Surgical Pain and Dysfunction in At-Risk Veterans: Effect of a Brief Behavioral Intervention (5R01NR017610-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9869049. Licensed CC0.

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