# Neuronal and Synapse-type specific Proteomics for Neurodevelopmental Disorders

> **NIH NIH R21** · HOWARD UNIVERSITY · 2020 · $231,750

## Abstract

Synaptic aberrations are commonly observed in a wide variety of neurodevelopmental disorders associated
with autism, epilepsy, intellectual disability and related phenotypes. While synaptic proteomic aberrations have
been identified in several models of neurodevelopmental disorders, these studies are mainly performed from
whole tissue samples and few provide data on synaptic alterations in a neuron-type or synapse-type specific
manner. Thus, synaptic alterations that are confined to specific types of synapses or neurons might be poorly
detected using this approach due to lack of technical sensitivity. The availability of a validated technique to
allow the detection of synaptic alterations in mouse models of human disorders in a neuron-type and synapse-type specific manner would accelerate our therapeutic efforts for disorders associated with synaptic
aberrations.
 In this discovery and validation proposal, we propose to mouse models of a neurodevelopmental disorder,
with known differential alterations in synaptic proteins in excitatory and inhibitory neurons, to define and
validate proteomic compositions of excitatory synaptosomes in a neuron type specific manner. The success of
our studies will allow great insights into the synaptic pathology neurodevelopmental disorders with synaptic
aberrations. The tools, techniques and approach can be applied more globally, thus promoting great strides in
cellular and molecular neuroscience.

## Key facts

- **NIH application ID:** 9869076
- **Project number:** 1R21NS114334-01
- **Recipient organization:** HOWARD UNIVERSITY
- **Principal Investigator:** Jyothi Arikkath
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $231,750
- **Award type:** 1
- **Project period:** 2020-06-01 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9869076

## Citation

> US National Institutes of Health, RePORTER application 9869076, Neuronal and Synapse-type specific Proteomics for Neurodevelopmental Disorders (1R21NS114334-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9869076. Licensed CC0.

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