# Translational Regulation of T Regulatory Cells

> **NIH NIH R01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $615,670

## Abstract

Project Summary
The goal of this work is to develop a fundamental understanding of the translational regulation of T regulatory
cell (Treg) development, of which very little is known, which can inform the development of more effective
therapeutic approaches to the regulation of Tregs in human cancer and autoimmune disease. Our research
has provided important insights into the molecular regulation of selective mRNA translation in Treg
development which we ultimately seek to capitalize on in generation of more effective immune-based
therapies. This work is directed to understanding and then targeting the privileged translation of Treg fate
determining mRNAs. The objective of our research is to determine the mechanism at the level of translational
control which key Treg mRNAs promote Treg development and immune suppression functions.

## Key facts

- **NIH application ID:** 9869845
- **Project number:** 5R01AI137067-03
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Robert Jay Schneider
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $615,670
- **Award type:** 5
- **Project period:** 2018-03-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9869845

## Citation

> US National Institutes of Health, RePORTER application 9869845, Translational Regulation of T Regulatory Cells (5R01AI137067-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9869845. Licensed CC0.

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