# Mechanisms of sound hypersensitivity in a rat model of autism

> **NIH NIH K01** · STATE UNIVERSITY OF NEW YORK AT BUFFALO · 2020 · $65,964

## Abstract

PROJECT SUMMARY
 Sensory hypersensitivity, particularly in the auditory realm, is one of the most common and debilitating
features of autism spectrum disorders (ASD). Not only is auditory hypersensitivity a core deficit and important
clinical problem in ASD, but it likely contributes to and reflects fundamental brain pathology that will extend to
more complex but less accessible features of autism, such as communication impairment and abnormal social
interaction. Thus, determining the nature of aberrant sound perception in ASD is a tractable model for
identifying core cellular and circuit alterations in ASD that also has direct clinical implications for unique
aspects of the disorder. I have developed novel behavioral paradigms to measure loudness growth and sound
intolerance in rodents. Using these tools, I determined that a well-validated rat model of Fragile X Syndrome
(FX), one of the leading inherited causes of ASD, exhibits exaggerated loudness perception and extreme
sound avoidance behavior, consistent with auditory hypersensitivity observed in a majority of FX individuals.
This proposal will combine these novel behavioral assays with high-density in vivo multi-electrode, ex vivo
whole-cell electrophysiological recordings, and novel cell-type specific chemogenetic manipulations to
determine how altered auditory network activity gives rise to aberrant sound perception and loudness
intolerance in Fmr1 KO animals. The results from these aims will: (1) offer insight into clinically relevant
features of FX and other autism-related disorders; (2) uncover fundamental neural disruptions at the core of
ASD pathophysiology; and (3) provide a novel platform for screening potential therapies for FX and ASD.
 The proposed research is both a logical extension and novel direction from my previous work in
neurodevelopmental disorders and the mechanisms of experience-dependent plasticity. With the guidance of
my mentor, co-mentors and collaborator, I will develop the experimental and intellectual tools for dissecting the
neural circuits involved the dynamic encoding of sensory information, and how these processes may be
disturbed in neurological disorders like autism and hyperacusis. The technical and professional training I would
receive here will be instrumental towards my ultimate goal of establishing an independent academic laboratory
where I can combine the above techniques to study how experience shapes functional brain circuits at multiple
levels of analysis, using the auditory system as a model that is also associated with direct clinical implications.

## Key facts

- **NIH application ID:** 9871333
- **Project number:** 1K01DC018310-01
- **Recipient organization:** STATE UNIVERSITY OF NEW YORK AT BUFFALO
- **Principal Investigator:** Benjamin D Auerbach
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $65,964
- **Award type:** 1
- **Project period:** 2020-04-10 → 2020-10-23

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9871333

## Citation

> US National Institutes of Health, RePORTER application 9871333, Mechanisms of sound hypersensitivity in a rat model of autism (1K01DC018310-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9871333. Licensed CC0.

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