# Husbandry & Management Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $145,174

## Abstract

PROJECT SUMMARY, Core A: Husbandry and Management Core
The U42 Grant is tasked to produce specific pathogen free (SPF4) Indian origin rhesus macaques (Macaca
mulatta) that are negative to simian immunodeficiency virus (SIV), simian T-lymphotropic virus (STLV-1),
simian retrovirus (type D retrovirus or SRV), and macacine herpesvirus-1 (BV), and are MHC class-1 typed.
The animals are also screened, but not excluded, for measles virus. SPF4 Indian origin rhesus macaques
have become the premier animal model for HIV/AIDS research, including studies on HIV pathogenesis, AIDS-
related opportunistic infections, and the development of HIV treatments and vaccines. AIDS/HIV research
demands for SPF4 Indian origin rhesus macaques are at an all-time national high and the demands are
projected to be higher over the grant cycle. The current U42 troop needs to increase in size to match the
increased demands for AIDS/HIV research requiring MHC typed, SPF4 Indian origin rhesus macaques. This
unique NHP colony is necessary to study the increasing range of viruses important to human infectious
disease studies, as well as the development and testing of novel viral vectors for AIDS/HIV. The overall aims
of the Husbandry and Management Core are to provide state-of-the-art husbandry care, veterinary care, and
colony management for a growing colony of U42 rhesus macaques large enough to support the increasing
needs of AIDS/HIV research.

## Key facts

- **NIH application ID:** 9873090
- **Project number:** 5U42OD010426-18
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Kirk Richard Andrews
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $145,174
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9873090

## Citation

> US National Institutes of Health, RePORTER application 9873090, Husbandry & Management Core (5U42OD010426-18). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9873090. Licensed CC0.

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