# Signals that Control Thymocyte Migration

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $382,155

## Abstract

   
DESCRIPTION (provided by applicant): Program Director/Principal Investigator (Robey, Ellen, A): Summary: T cells orchestrate immune responses, and defects in T cell development in the thymus can lead to auto- immunity or immunodeficiency. We have developed new methods to directly visualize and manipulate the pattern of TCR signaling during T cell development in living thymic tissue. By examining the impact of these manipulations on T cell development, we expect to gain insights into the mechanistic connections between TCR signaling, thymocyte migration, and different forms of T cell selection. Such information is key to developing improved treatments for a variety of immune system related diseases and to improving our ability to manipulate immune response to tumors or pathogens. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) 2 Page Continuation Format Page

## Key facts

- **NIH application ID:** 9873894
- **Project number:** 5R01AI064227-15
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** ELLEN A ROBEY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $382,155
- **Award type:** 5
- **Project period:** 2005-03-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9873894

## Citation

> US National Institutes of Health, RePORTER application 9873894, Signals that Control Thymocyte Migration (5R01AI064227-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9873894. Licensed CC0.

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