# A Comprehensive Functional Map of Human Protein-RNA Interactions

> **NIH NIH U41** · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · 2020 · $699,922

## Abstract

RESOURCE PROJECT - PROJECT SUMMARY
The overall goal of ENCORE (Encyclopedia of RNA Elements) is to provide protein-RNA interaction maps for
300 RBPs in 2 human cell lines, and associated localization, binding motif and functional datasets that aid in
interpretation of these data and assigning functions to the bulk of these RBPs. The goal of this resource project
is to generate and validate stable cell lines expressing epitope-tagged RNA binding proteins, perform primary
and integrated analysis of the human RBP physical and functional interaction data, and to develop publicly-
accessible transcriptomic, binding affinity and subcellular localization databases. These three goals are critical
to maximizing the impact of this resource by providing not only valuable physical resources to the community
(e.g. tagged cell lines) but also integrated analysis of the data to obtain as much insight as possible into the
functional and binding properties of each RBP. More importantly, making this data as accessible as possible to
a broad community of scientists will be achieved by making all data available at public data portals such as the
ENCODE DCC, as well as via our own web portals that host the datasets in formats amenable for web-based
queries and focused browsing. We will also conduct training sessions in the use of these tools. Finally, we will
facilitate reproducible data analysis by making all code we develop available using common workflow language
that can be used on any compute server and platform.

## Key facts

- **NIH application ID:** 9878910
- **Project number:** 5U41HG009889-03
- **Recipient organization:** UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
- **Principal Investigator:** Brenton R. Graveley
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $699,922
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9878910

## Citation

> US National Institutes of Health, RePORTER application 9878910, A Comprehensive Functional Map of Human Protein-RNA Interactions (5U41HG009889-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9878910. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*