# Emergence and Stability of Autism in Fragile X Syndrome

> **NIH NIH R01** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2020 · $595,646

## Abstract

   
DESCRIPTION (provided by applicant): Autism spectrum disorder (ASD) is a devastating and common neurodevelopmental disorder and a major public health concern. Fragile X syndrome is the leading known genetic cause of autism, and both fragile X syndrome and the FMR1 premutation are highly associated with autism with ~70% and ~20% meeting DSM- criteria respectively. This proposal extends our initial study, Emergence and Stability of Autism in Fragile X, focused on behavioral symptoms and biomarkers of ASD risk in infants with fragile X syndrome and fragile X premutation at 6,9,12 and 24 months contrasted to siblings of children with idiopathic ASD and typical controls. This proposal represents longitudinal surveillance at 3, 4 and 5 years-of-age in our cohort of 158 infant participants. Our initial findings have fueled a new set of questions to enhance our knowledge of the emergence of ASD features, diagnoses and associated features in FXS and FXpm, including the prevalence and stability of ASD diagnoses FXpm, the stability of ASD core features focused across a continuum, the association of atypical attention and social fear as additive or independent associated features and the predictive value of infant-derived prodromal features to ASD diagnoses across preschool.

## Key facts

- **NIH application ID:** 9878917
- **Project number:** 5R01MH090194-10
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **Principal Investigator:** Jane E Roberts
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $595,646
- **Award type:** 5
- **Project period:** 2011-05-27 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9878917

## Citation

> US National Institutes of Health, RePORTER application 9878917, Emergence and Stability of Autism in Fragile X Syndrome (5R01MH090194-10). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9878917. Licensed CC0.

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