# Engineering Personalized Devices for Craniomaxillofacial Defects

> **NIH NIH R33** · NEW YORK UNIVERSITY · 2020 · $390,081

## Abstract

Appropriate restoration of form and function of the missing skeletal tissue of growing children is a remarkable
challenge. Defects in the craniomaxillofacial bones of young children represent a significant emotional and
economic burden as their restoration/regeneration often requires multiple bone grafting procedures (usually
procured from the skull, hip, or ribs) for adequate treatment outcomes as the child grows. The recent
development of custom 3D printed degradable bioactive ceramic scaffolds that can fit and fill large bone
defects and quickly regenerate bone within defect margins may provide a novel solution and coating these
scaffolds with agents designed to promote more rapid and complete bone healing may increase the efficacy of
craniomaxillofacial bone defect treatment in growing children. Such an approach would eliminate the necessity
for secondary surgical sites for bone graft procurement and has tremendous potential to minimize/eliminate
multiple surgical procedures due to child growth, as the regenerated bone will follow the growth of adjacent
structures. The development of such a treatment option for skeletal defects would be an unprecedented
advance in bone reconstructive surgery of both growing children and that of adults. We have recently
conducted preliminary studies where customized 3D printed degradable bioactive ceramic scaffolds coated
with agents, which stimulate adenosine receptors (i.e. dipyridamole), remarkably enhanced bone regeneration.
The cellular and molecular basis for this effect is currently under investigation under 1R01AR068593-01.
Through this approach, we have successfully regenerated vascularized bone in rabbit models ranging from
critical size segmental defects of long bones and mandible to critical size defects of extremely thin and flat
bones of the craniomaxillofacial complex. Thus, we propose to test the hypothesis that 3D printed degradable
bioactive ceramic scaffolds coated with dipyridamole can promote rapid bone regeneration into a defect and
that the regenerated bone will normally follow adjacent structures’ growth and development in skeletally
immature subjects until full skeletal growth is complete. We therefore propose the following aims: To
maximize the combination of dipyridamole with personalized 3D printed bioactive scaffolds for the
repair of craniomaxillofacial defects in skeletally immature subjects and monitor the regenerated bone
over time. After successfully completing Aim I (R21), we will translate the developed technology to regenerate
and monitor over an extended period of time clinically relevant (human size) craniomaxillofacial defects in
skeletally immature highly translational large animal species, which presents bone tissue growth dynamics
more similar to human. Aim II. (R33) To translate the developed personalized 3D printed bioactive
ceramic scaffolds to treat craniomaxillofacial bone defects in a skeletally immature highly translational
animal species and monitor the regene...

## Key facts

- **NIH application ID:** 9882526
- **Project number:** 5R33HD090664-04
- **Recipient organization:** NEW YORK UNIVERSITY
- **Principal Investigator:** BRUCE Neil CRONSTEIN
- **Activity code:** R33 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $390,081
- **Award type:** 5
- **Project period:** 2019-03-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9882526

## Citation

> US National Institutes of Health, RePORTER application 9882526, Engineering Personalized Devices for Craniomaxillofacial Defects (5R33HD090664-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9882526. Licensed CC0.

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