# BioMedical Big Data Core

> **NIH NIH P20** · BROWN UNIVERSITY · 2020 · $617,951

## Abstract

PROJECT SUMMARY
The goal of this proposed COBRE Center is to unite computational and basic biological approaches to the
study of human disease. To support this general goal, the proposed Biomedical Big Data Core (BBD
Core) will build the necessary infrastructure for biomedical researchers at Brown and Affiliated Hospitals
to acquire, store, process, and analyze large-scale biomedical datasets. The near-term, primary mission
of the BBD Core is to support Junior Investigators in the analysis and interpretation of high-throughput
DNA/RNA sequencing datasets, including both data generated in their laboratories and large publically
available datasets. The BBD Core will serve as the central resource for big data analysis, and will address
the computational and analytical needs shared by multiple Junior Investigators, investigators who lack
resources to build the necessary resources within their research groups. The Core will also facilitate
scientific interactions between the projects in the COBRE, synergizing across common themes of
biomedical big data. The long-term goal of the BBD Core is to provide a sustainable resource to support
the big data challenges faced by contemporary genomics studies across Brown University and our
Affiliated Hospitals. This resource will enable biomedical researchers to focus on the scientific and
clinical challenges of such studies, while also avoiding unnecessary redundancy by building
computational/analytical expertise independently in each laboratory. The Core also provides training
for the broad research community to ensure the sustainability of next cohort of junior investigators.
 Dr. Benjamin Raphael and Dr. Zhijin Wu will be the faculty leaders of the BBD Core. This Core will
add four staff scientists to facilitate computational approaches to human disease research. A
Computational Biologist/Director will oversee routine operations and resources allocation. The database
developer will work with all projects to develop and maintain databases of project data and public
genomic databases. The computer programmer will develop pipelines for data processing and
implement existing and/or novel algorithms under the guidance of the director and COBRE Junior
Investigators. The Biostatistician will provide data analysis support.

## Key facts

- **NIH application ID:** 9882534
- **Project number:** 5P20GM109035-05
- **Recipient organization:** BROWN UNIVERSITY
- **Principal Investigator:** Benjamin Raphael
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $617,951
- **Award type:** 5
- **Project period:** — → 2021-08-03

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9882534

## Citation

> US National Institutes of Health, RePORTER application 9882534, BioMedical Big Data Core (5P20GM109035-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9882534. Licensed CC0.

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