# Liver Histology Core

> **NIH NIH P30** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $109,366

## Abstract

ABSTRACT
The Liver Histology (LH) Core is a newly-established Core, which has evolved as a result of its splitting from
the previous Cell and Tissue Imaging Core, under which it was a subcore (the other being previous Microscopy
Subcore). Histology services of RCLD started in 2007 in response to the growing-evolving needs of Center
Members and have expanded substantially over time, established an impressive track record of high-quality,
rapid turn-around service to our growing user base and remain in continuous high demand. The long-term
objectives of Liver Histology Core are the following: 1) Perform routine histology, i.e. regular paraffin
processing, sectioning and H&E, Sirius red and Oil red staining and provide assistance in interpretation and
quantitation of findings. 2) Cut unstained slides, which the users can then stain themselves. 3) Maintain a
deparaffination and dehydration line of chemicals under a hood, accessible to users. 4) Provide frozen
sectioning. 5) Add other services, based on the evolving needs of our user base (e.g. due to demand, we have
added TUNEL, caspase 3, PCNA, BrdU, Grp78, Cox IV, F4/80, myeloperoxidase and Ki67 stainings). 6)
Provide and train investigators in the use of the Core's state-of-the-art Leica LMD7000 laser microdissection
system and customized slide preparations. 7) Provide a stand-alone workstation with microscope, image
capture camera and processing software for independent and/or assisted use and analyses-interpretation of
histology images. 8) Assist investigators in development of immunohistochemistry for specific needs. 9) Assist
investigators in interpretation of histological findings and in the development of some quantitative and semi-
quantitative systems for scoring findings (e.g. necrosis, inflammation, fibrosis, steatosis).

## Key facts

- **NIH application ID:** 9883014
- **Project number:** 5P30DK048522-25
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Gary Kanel
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $109,366
- **Award type:** 5
- **Project period:** — → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9883014

## Citation

> US National Institutes of Health, RePORTER application 9883014, Liver Histology Core (5P30DK048522-25). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9883014. Licensed CC0.

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