# Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)

> **NIH NIH U01** · ALBERT EINSTEIN COLLEGE OF MEDICINE · 2020 · $557,267

## Abstract

ABSTRACT
Exposure to high doses of ionizing radiation results in injury to multiple organs causing acute radiation
syndrome. Bone marrow transplant (BMT) is an effective strategy to replace and regenerate injured stem
cells, it has proven to be very successful in mitigating radiation induced acute injury to the bone marrow (BM-
ARS). However at higher radiation doses and for non-hematopoietic injuries, BM mitigation alone is not
sufficient to rescue from mortality. For instance, acute radiation injury to the gastro-intestinal tract (GI-ARS) is
not mitigated by BMT or cytokine therapies. We have shown that GI-ARS can be successfully mitigated by
bone marrow adherent stromal cell transplant (BMASCT), consisting mainly of stromal and myeloid cells.
BMASCT in its current form is limiting when a large population is at risk, HLA libraries and well as allogeneic
cell transplant therapies are essential to developing this therapy for a large population. Current application
proposes various strategies to develop a radiomitigating cell product that can be used in a mass casualty
scenario.

## Key facts

- **NIH application ID:** 9886178
- **Project number:** 5U01AI138324-04
- **Recipient organization:** ALBERT EINSTEIN COLLEGE OF MEDICINE
- **Principal Investigator:** Chandan Guha
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $557,267
- **Award type:** 5
- **Project period:** 2018-03-09 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9886178

## Citation

> US National Institutes of Health, RePORTER application 9886178, Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS) (5U01AI138324-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9886178. Licensed CC0.

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