# Development of a 3D multi-modal perfusion-thermal electrode system

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $627,588

## Abstract

Summary/Abstract:
Title: Development of a 3D multi-modal perfusion-thermal electrode system
 Advances in image-guided interventional technologies have greatly improved the management of
malignancies in patients. Among different interventional oncologic techniques, thermal ablations, such
as radiofrequency ablation (RFA) and microwave ablation (MWA), have become the principal tools for
treatment of unresectable primary and metastatic malignancies. However, tumor recurrence post-
thermal ablation of medium (3-5 cm) to large (5-7 cm) lesions often occurs due to incomplete ablation
of tumor margins. To date, there is no an ideal image-guided interventional method for effective
management of medium-to-large solid organ malignancies.
 This project is specifically designed to conquer the critical clinical problem ─ persistence or
recurrence of medium-to-large malignancies post-thermal ablation, by development of a novel three-
dimensional (3D) multi-modal perfusion-thermal electrode system. To this end, we have proposed two
specific goals: (1) Aim I: to design and develop the novel 3D multi-modal perfusion-thermal electrode
system that is specifically built for using RFA-induced peri-tumoral RF hyperthermia (RFH) to
enhance direct chemotherapeutic destruction of tumor margins; and (2) Aim II: to validate the
technical feasibility of the new multi-modal electrode system with optimizing the technical protocols
via serial preclinical studies in living animal models with orthotopic liver tumors. As the first step of the
new technique development, we will primarily focus on the treatment of hepatic tumors by using first-
line chemotherapeutics. If successful, we will extend its application in treating malignancies to other
organs with more advanced therapies, such as gene therapy and immunotherapy.
 The success of this project will revolutionize current thermal ablation technology, leading to
significant advancement in eradicating medium-to-large malignant lesions, not only in the liver but
also in other solid organs. This will, in turn, greatly improve survival and quality of life of patients
suffering from medium-to-large malignancies.

## Key facts

- **NIH application ID:** 9886241
- **Project number:** 5R01EB028095-02
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** XIAOMING YANG
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $627,588
- **Award type:** 5
- **Project period:** 2019-04-01 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9886241

## Citation

> US National Institutes of Health, RePORTER application 9886241, Development of a 3D multi-modal perfusion-thermal electrode system (5R01EB028095-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9886241. Licensed CC0.

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