# Automated clinic blood pressure assessment and detection of white coat and masked hypertension study in African Americans

> **NIH NIH R01** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $792,860

## Abstract

Blood pressure (BP) measurement by a provider in the clinic, “attended clinic BP”, is the primary method for
diagnosing and managing hypertension (HTN). BP may differ inside versus outside of clinic. Ambulatory BP
monitoring (ABPM) measures out-of-clinic BP. Compared with attended clinic BP, BP during the awake period
on ABPM (“awake BP”) is a better predictor of cardiovascular (CVD) risk. Guidelines recommend ABPM to
identify white coat HTN (having high clinic BP but not having high awake BP) and masked HTN (not having
high clinic BP but having high awake BP). In most ABPM studies, white coat HTN is not associated with an
increased risk of target organ damage and CVD, whereas masked HTN is associated with a two times
increased risk of target organ damage and CVD. African Americans have a high prevalence of white coat and
masked HTN. A question has arisen: is there a better approach to measure clinic BP without the need to
conduct ABPM. One approach is to use an automated oscillometric device to measure clinic BP without a
provider present (“unattended clinic BP”). In prior studies, compared to attended clinic BP, unattended clinic
BP has been closer to awake BP, suggesting that unattended clinic BP may reduce the likelihood of white coat
HTN. However, these studies had several methodological limitations: the order of clinic BP measurements was
not randomized; attended and unattended clinic BP were not measured in the same individuals; attended clinic
BP measurement was not performed according to guidelines; and samples were small, did not include African
Americans, and only included those with high clinic BP. Scarce data also exist on whether unattended clinic BP
reduces the likelihood of masked HTN. The goal of the study is to determine whether unattended versus
attended clinic BP is closer to awake BP on ABPM, and whether unattended versus attended BP reduces the
likelihood of white coat and masked HTN. We will enroll 2,775 adults from the fourth exam of the Jackson
Heart Study (JHS), an African American cohort. Unattended and attended clinic BP measurement will be
performed in random order using the same oscillometric device with attended BP performed according to
guidelines; 24-hour ABPM will be conducted. Left ventricular hypertrophy (LVH) and chronic kidney disease
(CKD) will be assessed. In Primary Aim 1, we will compare the mean absolute within-individual difference
between clinic BP and awake BP on ABPM when clinic BP is measured unattended versus attended. In
Primary Aim 2, we will compare the group prevalence of white coat HTN and masked HTN when clinic BP is
measured unattended versus attended. In Primary Aim 3, we will determine whether masked HTN, defined
using unattended clinic BP, is associated with LVH and CKD. This study will provide high quality empiric
evidence which may impact future HTN guidelines. If unattended versus attended clinic BP is closer to awake
BP on ABPM, and the likelihood of both white coat and masked HTN are...

## Key facts

- **NIH application ID:** 9886967
- **Project number:** 1R01HL146636-01A1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Marwah Abdalla
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $792,860
- **Award type:** 1
- **Project period:** 2020-02-10 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9886967

## Citation

> US National Institutes of Health, RePORTER application 9886967, Automated clinic blood pressure assessment and detection of white coat and masked hypertension study in African Americans (1R01HL146636-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9886967. Licensed CC0.

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