# Hippo and Wnt Signaling in Cardiac Regeneration

> **NIH NIH R01** · TEXAS HEART INSTITUTE · 2020 · $588,687

## Abstract

This R01 application will investigate a novel signaling pathway, the Hippo pathway, in
mammalian heart regeneration. The long-term goal is to develop new treatments for
patients with heart failure by generating new cardiomyocytes in the adult heart. The
objectives of this application are to gain insight into molecular properties of cardiac
tissue that are regulated by Hippo signaling. The central hypothesis is that Hippo
signaling is a negative regulatory pathway that prevents cardiomyocyte regeneration in
the adult mammalian heart. The specific aims are to determine whether the Hippo and
Wnt pathways regulate adult heart repair in a manner similar to the interaction in
neonatal hearts. To determine whether an autonomous Wnt Hippo interaction occurs in
heart muscle nuclei to control important genes and to investigate whether Hippo
functions in a reversible manner. The project is conceptually and technically innovative.
Concepts to be tested include new ideas in cardiomyocyte biology and cutting edge
genome editing and interrogation technologies to address hypotheses. The significance
is high because there are no treatments for heart failure due to cardiomyocyte loss.
Devising ways to generate new cardiomyocytes is highly significant.

## Key facts

- **NIH application ID:** 9887526
- **Project number:** 2R01HL127717-05
- **Recipient organization:** TEXAS HEART INSTITUTE
- **Principal Investigator:** James F Martin
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $588,687
- **Award type:** 2
- **Project period:** 2016-01-15 → 2023-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9887526

## Citation

> US National Institutes of Health, RePORTER application 9887526, Hippo and Wnt Signaling in Cardiac Regeneration (2R01HL127717-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9887526. Licensed CC0.

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