# The Cleveland Digestive Diseases Research Core Center (DDRCC)

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2020 · $1,164,000

## Abstract

CLEVELAND DDRCC OVERALL PROJECT SUMMARY
This competitive renewal application is to obtain continued funding for the Cleveland Digestive Diseases
Research Core Center (DDRCC), which is a combined effort between Case Western Reserve University
(CWRU) and the Cleveland Clinic Foundation (CCF). The Cleveland DDRCC's mission is to: 1) enhance the
research capabilities of Center investigators, 2) develop and implement programs to support the independent
development of young investigators, 3) attract established investigators not currently involved in digestive
disease research to apply their expertise to this important area of investigation, and 4) facilitate the translation
of basic research discoveries to the clinical arena. This cross-institutional and multi-disciplinary Center
currently includes 47 full members and 35 associate members from 25 different academic departments across
CWRU and the CCF, representing a steady expansion during the previous funding cycle. Together, these
investigators comprise the Research Base for the Center, which currently consists of $17.3 million in peer-
reviewed federal and foundation grants (52 NIH, 5 DOD/VA, 10 private foundation grants) specifically related to
the two scientific themes of the Cleveland DDRCC: Digestive Inflammation/Tumorigenesis and Liver
Disease/Metabolism. These two programmatic areas have strong historical track records of collaborative
investigation at CWRU and the CCF and have shown significant growth in collaboration during the previous
funding cycle. The Center enjoys strong institutional support, including a commitment of significant matching
funds from both CWRU and the CCF to increase the impact of digestive disease research at both institutions.
The Center includes three biomedical research cores to support this strong Research Base: 1) a Biorepository
Core, 2) an Histology/Imaging Core, and 3) a Mouse Models Core, all of which have demonstrated high levels
of usage by Center members and promoted important scientific discoveries in digestive diseases during the
previous funding cycle. Each Core includes both a set of high-volume standard services that are best provided
as a shared resource that can optimize cost-efficiency and quality control, as well as more cutting-edge
advanced services and technologies that may not otherwise be available to Center investigators. The Core
laboratories interface with a Administrative Core, which also supports a successful Pilot and Feasibility
Program to promote innovative research projects by investigators who are new to the area of digestive
diseases. The Administrative Core oversees the financial management and operation of the Cleveland DDRCC
and supports a Clinical Element, as well as a dynamic Enrichment Program that has supported the meetings of
the Midwest DDRCC Research Alliance and two Cleveland International Digestive Education and Science
(IDEAS) Symposia during the previous funding cycle. The overall objective of the Cleveland DDRCC is t...

## Key facts

- **NIH application ID:** 9888512
- **Project number:** 2P30DK097948-06
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Fabio Cominelli
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,164,000
- **Award type:** 2
- **Project period:** 2015-02-15 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9888512

## Citation

> US National Institutes of Health, RePORTER application 9888512, The Cleveland Digestive Diseases Research Core Center (DDRCC) (2P30DK097948-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9888512. Licensed CC0.

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