# A prospective registry, biobank and observational study of food allergy

> **NIH NIH UM2** · JOHNS HOPKINS UNIVERSITY · 2020 · $2,839,184

## Abstract

Project Summary
Food allergy is a common disease that affects up to 15 million Americans. Although clinically there appears to
be a wide spectrum of disease, sub-types of food allergy with different clinical courses, co-morbidities and
responses to therapy have not been systematically identified. Identifying such sub-types of food allergy will
allow for tailored care of food allergic individuals. A second major research gap is our understanding of the
absolute risk and predictors of serious allergic reactions among those with food allergy who are receiving high
quality medical care. Establishing the risk and predictors of serious reactions will have critical implications for
determining the risk:benefit ratio for food allergy treatments, educating patients, identifying targets for reducing
risk, and determining the best candidates for treatment. This proposal is create a large repository, biobank and
prospective observational study of food allergic patients by enrolling 2000 subjects with IgE mediated milk, egg
or peanut allergy. Sub-types of food allergy will be identified using unsupervised methods based on
comprehensive clinical and immunologic data. The rate of reactions to foods will be closely monitored using
innovative mobile health technology. In addition to those major goals, the infrastructure created in this
observational cohort through the formation of a registry of well phenotyped food allergic patients and the
development of methods to monitor reactions will enable subsequent clinical trials funded by CoFAR to recruit
and proceed efficiently, and will provide samples for the opportunity fund. The specific aims of this project are:
(1) To establish a large registry and biobank of subjects with milk, egg and/or peanut allergy, (2) To establish
phenotypes of food allergy by clinically and immunologically characterizing food allergic individuals (Aim 2A)
and to identify predictors of these phenotypes (Aim 2B), and (3) To establish the rate of food allergic reactions
among individuals with food allergy (Aim 3A) and determine predictors of reaction frequency and severity (Aim
3B). The results of these investigations will help inform clinical care of food allergic individuals by allowing for
tailored care of food allergic individuals, and by informing the risk:benefit ratio for food allergy treatments. This
project will also critically advance research into food allergy by providing a registry from which to recruit
patients for CoFAR, data on phenotypes which can be used to shape future clinical investigations, and data on
predictors of reaction rates which can be used to design novel interventions.

## Key facts

- **NIH application ID:** 9889029
- **Project number:** 5UM2AI130836-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Corinne Keet
- **Activity code:** UM2 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,839,184
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9889029

## Citation

> US National Institutes of Health, RePORTER application 9889029, A prospective registry, biobank and observational study of food allergy (5UM2AI130836-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9889029. Licensed CC0.

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