# Role of TZAP in telomere homoeostasis

> **NIH NIH R01** · SCRIPPS RESEARCH INSTITUTE, THE · 2020 · $387,000

## Abstract

Project Summary
The goal of this proposal is to investigate the role of a novel Telomere associated protein that
we termed TZAP in telomere homeostasis. Telomeres are essential nucleoprotein structures
that cap chromosome ends. Alterations in telomere function are associated with various human
diseases including cancer, premature aging, dyskeratosis congenita, aplastic anemia, and
idiopathic pulmonary fibrosis. Our preliminary data show that TZAP is a novel telomere specific
binding protein that is involved in telomere length homoeostasis. Several questions remain to be
addressed to define the role of this novel telomere associated protein in telomere homeostasis.
To address this questions, we have devised a research proposal that will define the mechanism
of TZAP binding to telomeres, its role on telomere length regulation and the impact of its
depletion in respect to genome stability and tissue homoeostasis.

## Key facts

- **NIH application ID:** 9889147
- **Project number:** 5R01GM122987-04
- **Recipient organization:** SCRIPPS RESEARCH INSTITUTE, THE
- **Principal Investigator:** MICHAEL N BODDY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $387,000
- **Award type:** 5
- **Project period:** 2017-05-01 → 2021-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9889147

## Citation

> US National Institutes of Health, RePORTER application 9889147, Role of TZAP in telomere homoeostasis (5R01GM122987-04). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/9889147. Licensed CC0.

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