# Administrative Core

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $95,380

## Abstract

ADMIN CORE: Project Summary/Abstract
 The Administrative Core of the competing renewal of this Program Project Grant (PPG) entitled
“Frontotemporal Dementias: Genotypes and Phenotypes” is Core A. This PPG was launched 15 years ago
at the University of Pennsylvania and in the renewal period it will seek to advance understanding of
mechanisms underlying the onset and progression of hereditary and sporadic forms of frontotemporal
degeneration (FTD). These diverse clinical disorders are characterized by genetic and neuropathological
heterogeneity. For example, FTD with underlying frontotemporal lobar degeneration (FTLD) due to neuronal
and glial tau pathology (FTLD-Tau) account for ~45% of patients, while TDP-43 inclusions (FTLD-TDP)
account for ~50% of affected individuals, and ~5% of cases have FUS lesions (FTLD-FUS) as the underlying
neuropathology. Further, FTLD-Tau disorders, including corticobasal degeneration (CBD), progressive
supranuclear palsy (PSP) and Pick's disease (PiD), are linked to genetic and environmental risk factors, and
FTLD-Tau progression as well as heterogeneity may be driven mechanistically by the differential cell-to-cell
spread of different species or strains of pathological tau. The major focus of this PPG competing renewal is on
elucidating mechanisms underlying the onset, progression and heterogeneity of CBD, PSP and PiD. As the
administrative unit of this PPG, Core A continues to exercise fiscal and administrative oversight of the PPG,
facilitates interactions among PPG investigators to accomplish the PPG research goals, coordinates and
integrates activities of the Projects/Cores, and provides mechanisms to advise PPG Core and Project Leaders
on their progress towards accomplishing the mission of this PPG. This is achieved using strategies that have
been very successful in this PPG during the current funding cycle. Hence, Core A provides a clearly delineated
and proven administrative structure to foster and facilitate efforts by PPG investigators to elucidate
mechanisms of the onset/progression and pathobiology of hereditary and sporadic FTLD-Tau disorders,
especially CBD, PSP and PiD.

## Key facts

- **NIH application ID:** 9891002
- **Project number:** 5P01AG017586-20
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** VIRGINIA M LEE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $95,380
- **Award type:** 5
- **Project period:** — → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9891002

## Citation

> US National Institutes of Health, RePORTER application 9891002, Administrative Core (5P01AG017586-20). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9891002. Licensed CC0.

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