# Biostatistics and Data Management Core

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $133,942

## Abstract

BIOSTATISTICS & DATA MANAGEMENT CORE: Project Summary/Abstract
The Biostatistics and Data Management Core (Core E) proposal here is part of a Program Project Grant (PPG)
application to elucidate mechanisms of brain degeneration in hereditary and sporadic frontotemporal
dementias (FTD) or frontotemporal lobar degeneration (FTLD). This core supports all data management,
statistical, and computing needs, as well as maintains the PPG database for data from studies for all Cores
and Projects 1-4 within this PPG. The provided services include: (a) support for data form design and
development, database development and management, database audit trail, database security, database
backup, and stringent data quality control procedures; (b) computing and programming support for all PPG
activities, including implementation and integration of hardware and software upgrades necessary for data
management and research, as well as routine and archival off-site backup of computing systems central to the
PPG, including the PPG database; (c) biostatistical support for all study aspects from inception to publication,
including development of study design, performing sample size and power calculations, and performing
analyses of PPG data; and (d) development of new statistical methodologies where needed for data analysis.
Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct
of studies in this PPG. The studies proposed in this Core taken together with the complementary studies
conducted in the other 3 Cores and all 4 Projects in this PPG will lead to a better understanding of the
neurodegenerative mechanisms underlying FTLD, especially FTLD-Tau, which is likely to enhance efforts to
develop better diagnostics and therapeutic interventions for these disorders.

## Key facts

- **NIH application ID:** 9891009
- **Project number:** 5P01AG017586-20
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Sharon Xiangwen Xie
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $133,942
- **Award type:** 5
- **Project period:** — → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9891009

## Citation

> US National Institutes of Health, RePORTER application 9891009, Biostatistics and Data Management Core (5P01AG017586-20). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9891009. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*