# Aminoglycosides with reduced ototoxicity via miRNA targeting

> **NIH NIH R41** · NUBAD, LLC · 2020 · $397,674

## Abstract

PROJECT SUMMARY
 Aminoglycosides are one of the cheapest and well-known antibiotics in
clinical use for over 70 years, but one of the major limitations in their use is their
ototoxicity. We are developing fast and low cost methods to develop
aminoglycosides with anti- ribosomal activities and reduced toxicity. In this project,
we will identify novel aminoglycoside antibacterials, that show reduced ototoxicity.
Complexes between ribosomal components will be exploited as targets for small
molecule drug libraries that- inactivate the ribosome, stopping bacterial protein
synthesis and causing bacterial death while reducing toxicity. This work addresses
an important health issue, antibiotic ototoxicity, and presents creative steps towards
a novel solution to this problem.
 The work proposed here, a multidisciplinary effort using a miRNA binding and
inhibition approach, coupled with antibacterial screening and ototoxicity studies using
guinea pig models, describes the development and validation of a rapid way to
generate novel aminosugar rRNA binders as non-toxic antibacterial therapeutics. The
success of the proposed work would be a significant addition to currently available
approaches in antibacterial therapy. We propose using novel aminoglycoside
modifications and patented NUBAD assays to identify conjugates that show reduced
toxicities, opening possibilities for developing RNA targeted therapeutics with reduced
toxicity.

## Key facts

- **NIH application ID:** 9891947
- **Project number:** 5R41AI142856-02
- **Recipient organization:** NUBAD, LLC
- **Principal Investigator:** DEV PRIYA ARYA
- **Activity code:** R41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $397,674
- **Award type:** 5
- **Project period:** 2019-03-15 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9891947

## Citation

> US National Institutes of Health, RePORTER application 9891947, Aminoglycosides with reduced ototoxicity via miRNA targeting (5R41AI142856-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9891947. Licensed CC0.

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