# Core 1: Genomics and Data Management Core

> **NIH NIH P50** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $247,505

## Abstract

PROJECT SUMMARY 
Single cell RNA-seq and other transformative genomic technologies provide the opportunity to take human 
immunology to the next level of cellular detail, defining individual cells in greater orders of magnitude than 
previously possible. As a disease of great cellular heterogeneity, Systemic Lupus Erythematosus is ripe to be 
impacted by single cell technologies. The Genomics and Data Management Core (GDMC) will provide state- 
of-the-art genomics technologies and all data management capabilities for the proposed Center for Lupus 
Research. A major contribution of the GDMC will be to provide and develop the technology to analyze SLE 
patient samples with single cell resolution. Applying single cell technologies will help to define cell type 
characteristics in these patient populations, allow for specific comparisons between patient versus normal cell 
types and could potentially define new cell types associated with SLE and/or molecular subtypes of disease. 
Single cell RNA-seq will be used as a discovery tool to define cell populations and identify cell-type-specific 
markers. The flow and mass cytometry applications will utilize this information to develop new panels of 
antibodies that can be applied with greater throughput than single cell transcriptomics (i.e. on more patients 
and with greater numbers of cells per sample). Ultimately, the development of such a cellular phenotyping 
approach will enable improved stratification of SLE patients. In addition, the GDMC aims to provide the single 
cell tools to functionally interrogate new cell populations and pathways revealed by the resolving power of 
single cell transcriptomics, thus potentially uncovering new strategies for SLE therapeutics. The data 
management activities of the GDMC will ensure a unified and robust approach to experimental design and 
analysis for both research projects of the Center. GDMC will be responsible for the flow of data and information 
across all components of the Center and will be responsible for the submission of completed data sets/projects 
to the appropriate public archives. The Specific Aims for the GDMC are to 1) Provide state-of-the-art single 
cell transcriptomic technologies; 2) Provide state-of-the-art cellular phenotyping; and 3) Provide central 
storage, management and information security for data generated by the Center for Lupus Research. The core 
will thus fulfill essential scientific and translational needs across the Center through the application of powerful 
genomic technologies combined with expert data analysis and management support.

## Key facts

- **NIH application ID:** 9891958
- **Project number:** 5P50AR070594-04
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Paul Robson
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $247,505
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9891958

## Citation

> US National Institutes of Health, RePORTER application 9891958, Core 1: Genomics and Data Management Core (5P50AR070594-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9891958. Licensed CC0.

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