# Core B - Data Management, Harmonization, and Data Transfer Core

> **NIH NIH U54** · UNIVERSITY OF PENNSYLVANIA · 2020 · $1,204,753

## Abstract

Core B (Data Management, Harmonization, and Information Transfer) is mandated by RFA-AG-16001 as part
of the NIA Coordinating Center for Genetics and Genomics of Alzheimer's Disease (CGAD). Core B's primary
goal is to facilitate the analysis of the Replication Phase and Extended Replication Phase of the Alzheimer's
Disease Sequence Project (ADSP) by harmonizing all Alzheimer's disease (AD) relevant genotype and
phenotype data. The Replication Phase will use ADSP data and the Extended Replication Phase will use non-
ADSP data (Core A, Tables 3-5), and data for both phases will be harmonized by Core B. Harmonization will
use protocols developed by the ADSP and re-evaluated by Core C. Core B will produce fully annotated
analysis-ready files. These files/data will be distributed to Core C and all ADSP/RFA-AG16002 UO1 and AD
genetics investigators. Core C will develop and implement analyses plans, in collaboration with other
ADSP/RFA-AG16002 UO1 investigators (also see the Overall Component). Core B will provide the high-
performance computing infrastructure for computationally intensive tasks. Core B will manage all CGAD
phenotype, genotype, annotation, and analysis results, and distribute data/files to all ADSP/RFA-AG16002
investigators, to Genotypes and Phenotypes (dbGaP), and to NIA Genetics of Alzheimer's Data Storage Site
(NIAGADS). Specific tasks of Core B are: 1) Capture and maintain all relevant data including sequence data,
genotypes, phenotypes, analysis results, and other relevant data from ADSP Discovery Phase, Replication
Phase, and non-ADSP sources; 2) Harmonize genotype and phenotype data using protocols in collaboration
with Core C; 3) Impute single nucleotide variants (SNVs) for all genome-wide SNV array data using the
Haplotype Reference Consortium (HRC) reference panels and AD-specific variants from ADSP WES/WGS
data; 4) Call structural variants (SVs) for ADSP Replication and non-ADSP data; 5) Provide in silico annotation
analysis-ready files using the Genome Wide Annotation Resource (GWAR) and current ADSP protocols; 6)
Transfer information to ADSP, RFA-AG-16002 U01, and the general research community via CGAD/ADSP
website, relational databases, and NIA approved data repositories including dbGaP and NIAGADS; 7) Provide
infrastructure and support for CGAD computing and analyses.

## Key facts

- **NIH application ID:** 9892939
- **Project number:** 5U54AG052427-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** LI-SAN WANG
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,204,753
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9892939

## Citation

> US National Institutes of Health, RePORTER application 9892939, Core B - Data Management, Harmonization, and Data Transfer Core (5U54AG052427-05). Retrieved via AI Analytics 2026-07-07 from https://api.ai-analytics.org/grant/nih/9892939. Licensed CC0.

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