# Core C - Biostatistics and Data Analysis Core

> **NIH NIH U54** · UNIVERSITY OF PENNSYLVANIA · 2020 · $705,180

## Abstract

The role of the RFA-mandated Biostatistics and Data Analysis Core (Core C) in the Coordinating
Center for Genetics and Genomics of Alzheimer's Disease (CGAD) is to design and implement all
aspects of the analysis of Alzheimer's Disease Sequence Project (ADSP) and non-ADSP data
(Combined Discovery, Replication and Extended Replication Phases). This analysis design will occur
in collaboration with all ADSP/RFA-AG-16002 UO1 and other AD genetics investigators with Core C
leading this interaction. To this end, Core C personnel will work with Core A to establish mechanisms
for CGAD and other ADSP investigators to work together.
 The mission of the Core is to design analyses that make use of all available Alzheimer disease
(AD)-relevant genetics data including whole genome sequence (WGS) and whole exome sequence
(WES) from the ADSP Discovery Phase, targeted genome sequence (TGS) from the Replication
Phases, non-ADSP sequence data, and genome-wide single nucleotide variant (SNV) data from large
cohorts. Core C will design harmonization protocols for genetic data. Core B will execute these
protocols to prepare analysis-ready files for Core C analysis. Special consideration will be given to
family-based analyses because the multiplex kindreds being used by the ADSP and non-ADSP
groups for sequencing have additional subjects that are not being sequenced but with genome-wide
SNV data available. Special consideration will also be given to analyzing African American and
Caribbean Hispanic data.
 Core C tasks will be: 1) re-evaluate the Discovery Phase analyses for additional findings that may
be considered in the Replication Phase; 2) design and conduct Replication Phase analyses; 3)
design and conduct comprehensive analyses of the aggregate Discovery and Replication Phase data;
4) design and conduct analyses to incorporate genetic data generated outside the ADSP for subjects
and families used in the ADSP discovery and Replication Phases; 5) design and conduct the
Extended Replication Phase analyses to incorporate genetic data from subjects and cohorts not
directly involved in the ADSP project; 6) design post analyses; 7) develop novel analyses
approaches.

## Key facts

- **NIH application ID:** 9892940
- **Project number:** 5U54AG052427-05
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** GERARD DAVID SCHELLENBERG
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $705,180
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9892940

## Citation

> US National Institutes of Health, RePORTER application 9892940, Core C - Biostatistics and Data Analysis Core (5U54AG052427-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9892940. Licensed CC0.

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