# Metabolomics study in patients post myocardial infarction

> **NIH VA I01** · VA NORTHERN CALIFORNIA HEALTH CARE SYS · 2021 · —

## Abstract

ABSTRACT
 This proposal represents a bench-to-bedside study to translate our recent findings in small animal models
into the clinic. Cardiac remodeling is the heart’s prevailing response to extrinsic and intrinsic stimuli including
pressure or volume overload, mutations of sarcomeric proteins, or loss of contractile mass from myocardial
infarction (MI). Adverse cardiac remodeling is driven at the cellular level by myocyte hypertrophy, apoptosis,
microvascular dysfunction, fibrosis, and electrical perturbations. Our group was the first to demonstrate
beneficial effects of a novel class of soluble epoxide hydrolase (sEH) inhibitors in clinically relevant models of
cardiac hypertrophy and failure. SEH is a critical enzyme in the cytochrome P450 pathway. Treatment with
sEH inhibitors (sEHIs) results in the prevention of ventricular myocyte hypertrophy and electrical remodeling in
pressure overload and myocardial infarction models. Our findings further demonstrate that treatment with
sEHIs prevents cardiac fibroblast proliferation and fibrosis. This project is focused on the novel concept that
pro-inflammatory metabolites of the cytochrome P450 pathway can result in adverse cardiac remodeling by
increasing cardiac myocyte hypertrophy, apoptosis, coupled with a persistent increase in cytokines and
chemokines leading to an increase in cardiac fibrosis. Hence, the main objective of this proposal is to use
novel metabolomic profiling to determine the mechanistic roles of lipid mediators in adverse cardiac remodeling
in patients post MI. New treatment paradigms for adverse cardiac remodeling are likely to be highly impactful.

## Key facts

- **NIH application ID:** 9892972
- **Project number:** 5I01CX001490-04
- **Recipient organization:** VA NORTHERN CALIFORNIA HEALTH CARE SYS
- **Principal Investigator:** Nipavan Chiamvimonvat
- **Activity code:** I01 (R01, R21, SBIR, etc.)
- **Funding institute:** VA
- **Fiscal year:** 2021
- **Award amount:** —
- **Award type:** 5
- **Project period:** 2017-04-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9892972

## Citation

> US National Institutes of Health, RePORTER application 9892972, Metabolomics study in patients post myocardial infarction (5I01CX001490-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9892972. Licensed CC0.

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