# Models and Methods for Population Genomics

> **NIH NIH R01** · PRINCETON UNIVERSITY · 2020 · $356,951

## Abstract

Project Summary
Title:
Models and Methods for Population Genomics
Abstract:
Understanding genome-wide genetic variation and its role in health-related complex traits in humans is one of
the most important goals of modern biomedical research. There continues to be a substantial need for new
statistical models and methods that can be applied in these studies, particularly as study designs become
more ambitious and sample sizes increase. The overall goal of the proposed research is to develop statistical
methods and software useful in understanding population genomics studies that involve genome-wide
genotyping, many simultaneously measured traits, and very large sample sizes. Our focus is on flexible
modeling that adapts to systematic variation and robustly models data encountered in these modern studies.
The specific aims involve (1) developing tests of association immune to arbitrary population structure that work
for general distributions of traits, many simultaneous traits, or extreme large sample sizes; (2) introducing new
models and estimates of kinship and FST in generalized settings, which will lead to improved quantitative
genetic modeling of complex traits; (3) introducing new estimation and testing frameworks for population
structure that show superior performance to existing approaches; (4) developing and distributing software; and
(5) analyzing important data sets to discover new biology and validate our methods and software.

## Key facts

- **NIH application ID:** 9893014
- **Project number:** 5R01HG006448-07
- **Recipient organization:** PRINCETON UNIVERSITY
- **Principal Investigator:** JOHN D STOREY
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $356,951
- **Award type:** 5
- **Project period:** 2012-08-25 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9893014

## Citation

> US National Institutes of Health, RePORTER application 9893014, Models and Methods for Population Genomics (5R01HG006448-07). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9893014. Licensed CC0.

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