# Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

> **NIH NIH R44** · VOLUMETRIX, LLC · 2020 · $768,395

## Abstract

Volume overload (congestion) occurs in patients with heart failure (HF) and is the leading cause
of hospitalization in the elderly worldwide. Unfortunately, clinical signs and symptoms;
laboratory values; and existing diagnostic tools are unreliable in providing accurate assessment
of volume status. Using a unique physiologic signal, Non-Invasive Venous waveform Analysis
(NIVA), VoluMetrix has developed a proprietary device (“VasaWatch”) and algorithm designed
for monitoring volume status in HF patients. Proof of concept data in humans and experimental
animal models, demonstrate that VasaWatch provides a reliable indication of intravascular
volume status. The studies in this Fast Track SBIR will establish that VasaWatch is a safe,
sensitive, inexpensive method for non-invasive volume status monitoring in patients with HF.

## Key facts

- **NIH application ID:** 9893023
- **Project number:** 5R44HL140669-03
- **Recipient organization:** VOLUMETRIX, LLC
- **Principal Investigator:** Kyle Mitchell Hocking
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $768,395
- **Award type:** 5
- **Project period:** 2018-08-21 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9893023

## Citation

> US National Institutes of Health, RePORTER application 9893023, Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF) (5R44HL140669-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9893023. Licensed CC0.

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