# The Role of the Hippocampus in Early Memory for Words

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $235,500

## Abstract

PROJECT SUMMARY
Episodic memory, or the ability to remember past events with specific detail, is central to the human
experience and is related to learning and adaptive functioning in a variety of domains. In typically developing
children, episodic memory improves emerges during infancy and improves during early childhood and beyond.
Despite remarkable early episodic memory skills, most early recollections are lost to infantile amnesia,
individuals' inability to recall events occurred in the first 2 or 3 years of life. Developmental processes within the
hippocampus are hypothesized to be primarily responsible for both the early emergence of episodic memory in
children and the loss of early recollections due to infantile amnesia. However, these hypotheses are based on
non-human models and in-vivo investigations in early human development have been significantly limited by
the methodological challenge of acquiring neuroimaging data, particularly task-related functional neuroimaging
data, from young children.
Recent studies in adults have highlighted that the hippocampus is involved in the acquisition of the initially
arbitrary association between new words and their referents, a capacity markedly impaired in hippocampal
amnesia. We propose to leverage the remarkable word-learning skills in infants and toddlers to explore
whether neural substrates of memory for words can be used as a marker of early episodic memory.
The proposed research will explore new methods to test hippocampal structure and function in infants and
toddlers ages 18 to 30 months, a period during which episodic memory improves, hundreds of words are being
learned, but infantile amnesia operates.
Relevance to Public Health: Healthy episodic memory provides a foundation for the emergence and
development of autobiographical memory, continuity of self from past to future, and is associated with
intellectual ability and academic achievement. The development of episodic memory is impaired following even
mild forms of acquired neurological insult, mental health conditions such as anxiety and depression, and
neurodevelopmental disorders; language acquisition is additionally impaired in a number of disorders
underscoring that a characterization of memory and vocabulary development is key to understanding adaptive
functioning in various populations of children.

## Key facts

- **NIH application ID:** 9893909
- **Project number:** 5R21HD098700-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** SIMONA GHETTI
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $235,500
- **Award type:** 5
- **Project period:** 2019-03-15 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9893909

## Citation

> US National Institutes of Health, RePORTER application 9893909, The Role of the Hippocampus in Early Memory for Words (5R21HD098700-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9893909. Licensed CC0.

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