# Functional impact of fixational eye movements in central vision loss

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA BERKELEY · 2020 · $198,750

## Abstract

PROJECT SUMMARY/ABSTRACT
People who lose their central (foveal) vision due to macular disorders such as age-related macular degeneration
or other retinal diseases often suffer from poor vision that cannot be corrected optically, surgically or
therapeutically. To date, there is no promising cure for macular disorders, and there is no intervention that can
reverse the vision loss. Previous efforts to understand why vision is so difficult for people with central vision loss
have focused mainly on the spatial properties associated with using the peripheral retina. This project examines
a different factor — the effects due to fixational eye movements. Most individuals with central vision loss have
unsteady fixation, resulting in greater retinal image motion than that found in people with normal vision. The
clinical wisdom is that exaggerated fixational eye movements are detrimental for vision. Is it really so? People
with central vision loss must use their peripheral vision, therefore, potentially the exaggerated fixational eye
movements are beneficial because they prevent images on the peripheral retina from fading. This research will
be the first attempt in providing scientific evidence to understand the relationship between fixational eye
movements and functional vision in people with central vision loss.
The first aim of the proposed research project is to test the hypothesis that the retinal image motion associated
with fixational eye movements exhibited by people with central vision loss is suboptimal for them to see “fine”
details. We will evaluate how performance for fine spatial tasks changes with the amount of retinal image motion,
generated by stabilizing (to different extent) a stimulus on the retina using an eye-tracking scanning laser
ophthalmoscope. We expect that performance vs. the amount of retinal image motion would demonstrate tuning:
Too little retinal image motion would cause perceptual fading (poorer vision) and too much retinal image motion
would be detrimental for seeing spatial details. We predict that for any given individual with central vision loss,
there is an optimal level of retinal image motion that yields the best functional vision, which may not correspond
to that due to the natural fixational eye movements of the individual.
The second aim of the proposed research project is to test the hypothesis that retinal image motion due to
abnormal fixational eye movements can be reduced through fixation training. More importantly, the improved
fixation stability after training will be accompanied by improvements in functional vision. We will compare
performance on several common visual tasks, and the shape of the tuning function as described in the first aim,
before and after fixation training to evaluate the efficacy of the fixation training. Retention of the training effect
will also be examined.
The findings from this project will help us understand the role of fixational eye movements in limiting vision for
people with c...

## Key facts

- **NIH application ID:** 9894338
- **Project number:** 1R21EY030253-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Susana T Chung
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $198,750
- **Award type:** 1
- **Project period:** 2020-09-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9894338

## Citation

> US National Institutes of Health, RePORTER application 9894338, Functional impact of fixational eye movements in central vision loss (1R21EY030253-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9894338. Licensed CC0.

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