# Mouse Support Core

> **NIH NIH P01** · UNIVERSITY OF VIRGINIA · 2020 · $399,790

## Abstract

CORE B PROJECT SUMMARY
The primary goals of this Program Project application are to understand the function of pannexin channels in
normal physiology, as well as well as under conditions of cardiovascular and inflammatory diseases. This Mouse
Support Core/Core B will serve all projects in the following ways: (1) This core will provide the husbandry,
genotyping and basic crossing of conditional Panx1 knockout mice to specific Cre strains; specifically, the
Panx1fl/fl mice crossed to at least five different Cre strains that are relevant to studying cardiovascular and
inflammatory diseases. (2) This Core will also help generate additional transgenic Panx1 mice for tissue-specific
expression of Panx1-WT and variants. (3) The Core will generate Cre-mediated tissue-speficic knockouts of the
Panx1-regulatory proteins Sik1 and LKB1. The key benefits of this Mouse Support Core are that it will help
consolidate the breeding and mouse maintenance, save time and cost, and avoid variations due to colonies
individually maintained by the four project leaders. As the previous funding period has shown, having a dedicated
core to cross the various Cre strains will be a huge advantage to all four projects. Moreover, the innovative
transgenic mouse models overexpressing wild type or mutant forms of Panx1 will help answer key questions
posed in the four main Projects in additional unique ways. Collectively, these mouse strains/models and analyses
tools generated are expected to be fundamentally important in advancing our work to human disease, and will
also help the larger community of researchers studying pannexin channel function pertaining to many human
diseases.

## Key facts

- **NIH application ID:** 9894835
- **Project number:** 5P01HL120840-07
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Ulrike Lorenz
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $399,790
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9894835

## Citation

> US National Institutes of Health, RePORTER application 9894835, Mouse Support Core (5P01HL120840-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9894835. Licensed CC0.

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