# Mass Spectrometry / Proteomics Shared Facility

> **NIH NIH P30** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $251,939

## Abstract

MOLECULAR ANALYSIS / TRANSLATION GROUP
MASS SPECTROMETRY / PROTEOMICS SHARED FACILITY (MSPSF)
ABSTRACT
The over-arching goal of the Mass Spectrometry/Proteomics Shared Facility (MSPSF) is to provide state-of-
the-art capabilities and training in mass spectrometry, proteomics, and bioanalytical technologies to support
the research needs of UAB Comprehensive Cancer Center (UAB-CCC) members. The MSPSF is a research
resource that provides services to UAB-CCC members that support the identification, characterization and
quantification of proteins, as well as post-translational modifications. The proteins may be isolated from cells,
biological fluids and tissues (fresh, frozen or formalin-fixed paraffin-embedded [FFPE]). The MSPSF has
streamlined and standardized its operations and offers cost-effective, high quality services to UAB-CCC
members through utilization of standardized workflows and operating procedures that cover a wide range of
applications including the identification of specific post-translational changes, global and targeted quantitative
proteomics, and structural biology. The interface between data gathering and analysis has been strengthened
and now includes basic and advanced informatics applications. In the current funding cycle, the MSPSF has
expanded its services in response to the emerging needs and thematic emphasis of the UAB-CCC through
initiatives undertaken in collaboration with other UAB-CCC Shared Facilities. These include the development
and validation of robust proteomic analysis carried out using FFPE tissues from mouse and human and
development of reagents and animals that permit utilization of approaches based on stable isotope-labeled
amino acids in mice (SILAM).
The MSPSF supports basic and clinical research within all six programs of the UAB-CCC that is focused on
mass spectrometry/proteomics analyses of proteins in either purified or complex biological samples. During the
current funding cycle 48 UAB-CCC members utilized the MSPSF to further their cancer research. Information
gained provides critical insights that include biomarker discovery for disease diagnosis, progression, and
therapeutic response; including changes in cellular pathways associated with a specific process. The services
provided play an important role in translating basic science discoveries to clinical applications in the treatment
of cancer.

## Key facts

- **NIH application ID:** 9895643
- **Project number:** 5P30CA013148-48
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** James A Mobley
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $251,939
- **Award type:** 5
- **Project period:** — → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9895643

## Citation

> US National Institutes of Health, RePORTER application 9895643, Mass Spectrometry / Proteomics Shared Facility (5P30CA013148-48). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9895643. Licensed CC0.

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