# Transgenic Animal Shared Facility

> **NIH NIH P30** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $197,286

## Abstract

MOLECULAR ANALYSIS / TRANSLATION GROUP
TRANSGENIC ANIMAL SHARED FACILITY (TASF)
ABSTRACT
The UAB Transgenic Animal Shared Facility (TASF) is a vital component of the UAB Comprehensive Cancer
Center, and its research enterprise. Genetically modified mouse models continue to be the most tractable
mammalian system to examine the role of an identified genetic variant associated with human disease, as well
as creating much needed translational models for developing novel therapeutics. This shared facility provides
unique services for the development of genetically modified animal models and has a long track record of
outstanding service. The specific aims include:
1. Provide efficient, cost-effective production of transgenic and genetically-engineered animal models for
Comprehensive Cancer Center investigators. To enhance cancer research the core will continue its productive
history of developing novel mouse models by microinjection of gene constructs into fertilized mouse eggs or
ES cells into blastocysts, and additionally now offers services to create both rat and zebrafish genetic models.
2. Provide additional essential services in animal model development and support. Development and
management of animal models will include: TALEN and CRISPR synthesis and gene targeting,
cryopreservation of embryos and sperm, embryo re-derivation to produce pathogen-free animals, assisted
reproduction techniques (e.g., in vitro fertilization [IVF], superovulation, and embryo transfer).
3. Provide expert consultation services to help investigators design the most effective transgene and gene
targeting constructs, strategies for molecular identification, and breeding strategies required for generating
genetically modified experimental animals and appropriate control animals.
The services provided are not available through any other mechanism except external commercial or academic
alternatives that do not supply the complete set of services provided by this facility, or are prohibitively costly in
terms of both expense and/or time impediments.

## Key facts

- **NIH application ID:** 9895646
- **Project number:** 5P30CA013148-48
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** ROBERT A KESTERSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $197,286
- **Award type:** 5
- **Project period:** — → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9895646

## Citation

> US National Institutes of Health, RePORTER application 9895646, Transgenic Animal Shared Facility (5P30CA013148-48). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9895646. Licensed CC0.

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