# Sensorimotor impairments in men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: relationship of resting state brain activity to pelvic floor muscle activation

> **NIH NIH R01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $332,335

## Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and often debilitating condition. The
underlying cause of CP/CPPS remains unknown. We recently published the first neuroimaging study
comparing men with CP/CPPS to healthy men. We found that, most importantly, the functional connectivity
between a brain motor region that activates pelvic floor muscles and a viscerosensory region in the right
posterior insula was significantly reduced in men with CP/CPPS compared to healthy men. This prior work
suggests that understanding this sensorimotor functional connection, which we term pelvic-motor/right-
posterior-insula functional connectivity, may be critical to understanding the pathophysiology of CP/CPPS.
However, we still do not fundamentally know how resting brain function influences active sensorimotor control.
In the proposed work, we aim to fill this knowledge gap by relating pelvic-motor/right-posterior-insula functional
connectivity to automatic pelvic floor muscle activation during voluntary activation of non-pelvic floor muscles in
men with and without CP/CPPS. We will recruit 52 men with CP/CPPS and 52 healthy men. In each participant,
we will use resting-state functional Magnetic Resonance Imaging (rs-fMRI) to quantify pelvic-motor/right-
posterior-insula functional connectivity, surface EMG to quantify automatic pelvic floor muscle activation during
voluntary gluteal muscle activation, and questionnaires to quantify CP/CPPS pain intensity. rs-fMRI, EMG, and
pain measures will be analyzed with the following Aims. In Aim 1, we will study inter-individual differences in
men and determine if reduced pelvic-motor/right-posterior-insula functional connectivity correlates with
increases in the magnitude of automatic pelvic floor muscle activation during voluntary activation of non-pelvic
floor muscles. In Aim 2, we will compare healthy men and men with CP/CPPS, whom we have shown to have
a reduced value of resting state pelvic-motor/right-posterior-insula functional connectivity compared to healthy
male controls. We will determine if men with CP/CPPS show corresponding increases in the magnitude of
automatic pelvic floor muscle activation during voluntary activation of the gluteus maximus muscle, and if the
magnitude of automatic pelvic floor muscle activation is correlated with the intensity of CP/CPPS pain. This
work, to our knowledge, represents the first study relating resting brain function to the magnitude of automatic
muscle activation during movement. This work is also the first study proposing to test a specific mechanism of
altered pelvic floor muscle control in men with CP/CPPS. Our prior work defined a brain connection of interest
in men with CP/CPPS. Our proposed work will determine if this brain connection is related to altered
movement control. Our future work will be able to then examine modifying movement control as an approach to
restoring normal brain function in men with CP/CPPS.

## Key facts

- **NIH application ID:** 9896815
- **Project number:** 5R01DK110669-04
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Jason J. Kutch
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $332,335
- **Award type:** 5
- **Project period:** 2017-02-01 → 2022-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9896815

## Citation

> US National Institutes of Health, RePORTER application 9896815, Sensorimotor impairments in men with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: relationship of resting state brain activity to pelvic floor muscle activation (5R01DK110669-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9896815. Licensed CC0.

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