# Simultaneous Hadamard Editing of GABA and Glutathione

> **NIH NIH R01** · JOHNS HOPKINS UNIVERSITY · 2020 · $367,756

## Abstract

PROJECT SUMMARY
Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration
metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox
compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR
spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest.
Such “edited” approaches generally focus on measuring a single metabolite (i.e. either GABA or
GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited
experiments that detect GABA and GSH simultaneously, in a single acquisition.
We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing,
using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post-
processing and analysis tools will be made available for dissemination to the clinical
neuroscience and neuroimaging communities.

## Key facts

- **NIH application ID:** 9896825
- **Project number:** 5R01EB023963-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Richard Anthony Edward Edden
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $367,756
- **Award type:** 5
- **Project period:** 2017-05-05 → 2021-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9896825

## Citation

> US National Institutes of Health, RePORTER application 9896825, Simultaneous Hadamard Editing of GABA and Glutathione (5R01EB023963-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9896825. Licensed CC0.

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