# Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome Editing

> **NIH NIH R35** · UNIVERSITY OF PENNSYLVANIA · 2020 · $810,833

## Abstract

PROJECT SUMMARY
For the past 6 years, my independent laboratory has leveraged new approaches in human genomics and
pioneered new types of post-genomic functional studies—empowered by genome-editing technologies—to
elucidate novel mechanisms that drive cardiovascular diseases. My laboratory has characterized the roles of
specific genes involved in lipid metabolism, coronary heart disease, and diabetes, as well yielding insights into
how noncoding DNA variation influences the functions of these genes. Going forward, my research will take
advantage of recent advances in disease modeling and therapeutic genome editing—advances in which my
laboratory played a part—to tackle two exemplary translational challenges in the cardiovascular field: (1)
the use of therapeutic genome editing to prevent coronary heart disease, the leading cause of death
worldwide; and (2) the use of genome editing to empower high-throughput functional annotation of variants
of uncertain significance detected in patients by clinical sequencing.

## Key facts

- **NIH application ID:** 9896848
- **Project number:** 5R35HL145203-02
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Kiran Musunuru
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $810,833
- **Award type:** 5
- **Project period:** 2019-03-20 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9896848

## Citation

> US National Institutes of Health, RePORTER application 9896848, Diagnosis, Prevention, And Treatment Of Cardiovascular Diseases With Genome Editing (5R35HL145203-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9896848. Licensed CC0.

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