# Pathogenesis and Symptomatology of Pediatric Myeloproliferative Neoplasms

> **NIH NIH K23** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $184,311

## Abstract

Project Summary
This project will allow us to obtain a greater understanding about Myeloproliferative Neoplasms (MPN) in
children. The specific aims of this proposal are to develop symptom profiles by creating a symptom
assessment tool for children with MPN and examine cytokine and protein derangements, and to identify
causative lesions for these diseases using a targeted genetic analysis (since these lesions are likely different
than the causative lesions identified in adults with MPN.) We have begun to leverage a state-of-the-art
genomics platform, analyzing 600 genes relevant to MPN and hematological malignancies, to identify novel
targets in pediatric MPN patients. The long-term goals include gaining an understanding of the genotypic-
phenotypic correlations of MPN so that risk stratifications and treatment algorithms can be designed to manage
these children, as well as identifying new or relevant molecular targets for novel therapies to be used in
children with MPN, and to allow for future clinical trials to be developed in this population. This proposal will
help the PI develop the additional skills needed to become an independent clinical researcher and physician-
scientist specializing in pediatric MPN, through research plans, formal didactic coursework, and individual
tutorials with her expert advisory committee members. This proposal is highly relevant to the NHLBI's mission
of translating basic discovery into clinical practice and helping improve the health and lives of individuals living
with blood diseases.

## Key facts

- **NIH application ID:** 9897587
- **Project number:** 5K23HL127223-04
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Nicole Kucine
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,311
- **Award type:** 5
- **Project period:** 2017-04-27 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9897587

## Citation

> US National Institutes of Health, RePORTER application 9897587, Pathogenesis and Symptomatology of Pediatric Myeloproliferative Neoplasms (5K23HL127223-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9897587. Licensed CC0.

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