# Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global Health

> **NIH NIH K24** · EMORY UNIVERSITY · 2020 · $184,334

## Abstract

PROJECT SUMMARY / ABSTRACT
Tuberculosis (TB) is the leading cause of infectious disease death globally, and accounts for 4 out of 10 deaths
in HIV-infected individuals. Although progress has been made in decreasing incidence and mortality from TB,
the current trends are woefully insufficient to achieve the WHO End TB goal of fewer than 10 TB cases per
100,000 population by 2035. Innovative research to develop new diagnostic, therapeutic and prevention tools
are critically needed. Thus, training the next generation of scientists with expertise to carry out translational
studies in TB and TB/HIV co-infection in high burden settings is an important priority. The goal of this K24
competitive renewal is to continue to mentor promising young investigators in clinical and translational patient-
oriented research in TB, HIV and Global Health. My current K24 has been very successful in supporting
mentorship for 33 trainees, and in allowing me to expand my research program substantially to include
molecular epidemiology, TB immunology and clinical trials. The current K24 supported 36 publications,
including 26 with a mentee as first author. Mentees were also successful in submitting extramural grants,
including NIH K career development awards and making the transition from K awards to their first R01 grants.
In this competitive renewal, I will expand my own training to: 1) understand how human genetics and
epigenetics can elucidate mechanisms underlying susceptibility and resistance to Mtb infection; 2) gain further
expertise in spatial epidemiology and spatial statistics to inform studies of TB transmission; and 3) enhance my
mentorship and leadership skills to prepare my trainees for careers in patient-oriented research. This additional
training will enhance my mentorship of trainees participating in our ongoing R01 studies examining: the role of
casual contact in TB transmission; and host genetic polymorphisms associated with resistance to Mtb infection.
The K24 continuation will also facilitate a pilot epigenetic study investigating two novel specific research aims:
1) to assess candidate DNA methylation sites for association with resistance to Mtb infection; and 2) to identify
epigenetic predictors of resistance to Mtb infection using an epigenome-wide approach. The research from my
ongoing R01 studies and the proposed new pilot study will generate novel insights into factors associated with
TB transmission and susceptibility to Mtb infection to inform the development of epidemiologic interventions
and preventive therapeutics to reduce the number of new Mtb infections. Further, the data and specimens
generated will provide numerous training opportunities for my mentees to develop their own career
development projects.

## Key facts

- **NIH application ID:** 9898222
- **Project number:** 5K24AI114444-07
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Neel Rajnikant Gandhi
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $184,334
- **Award type:** 5
- **Project period:** 2014-06-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9898222

## Citation

> US National Institutes of Health, RePORTER application 9898222, Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global Health (5K24AI114444-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9898222. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*