# Physiology Core

> **NIH NIH P30** · YALE UNIVERSITY · 2020 · $248,839

## Abstract

Abstract
The primary objective of the Physiology Core is to provide DRC members with access to centralized facilities,
services and technical expertise to address complex metabolic questions related to diabetes using normal,
diabetic or genetically modified rodent models. The core is structured into two Sub-cores, the Animal Surgery
and Experimental Procedure Sub-core and the Analytical Sub-core, each of which contains specialized
equipment and key personnel to help DRC investigators and/or their trainees achieve their tasks in the most
efficient and cost-effective manner. It also serves as a forum for collaboration between members with different
research backgrounds, but a common interest in studying diabetes. Through the Animal Surgery and
Experimental Procedure Sub-core, DRC investigators gain access to training, equipment, laboratory facilities
and technical expertise to perform complex rodent surgeries, including the placement of vascular catheters and
other implantables, such as brain micro-injection and micro-dialysis probes. Core staff help carry out complex
metabolic studies using specialized experimental methodologies (e.g. glucose clamps, tracers, microdialysis
and amperometric studies) in conscious mice and rats – skills that are not easily accessible to investigators
without previous training or experience, particularly young investigators, fellows, and pilot award recipients.
The Analytical Sub-core provides DRC members with a central facility for the measurement of
glucoregulatory hormones, cytokines and neurotransmitters specifically derived from rodent studies. This
component of the Physiology Core benefits from the expertise and equipment of an on-going and prolific
radioimmunoassay and HPLC facility. Expansion of the repertoire of mass spectrometry-based assays and
establishment of a DRC - Mass Spectrometry Shared Resource to measure cytokines and neurotransmitters
and to offer state-of-the-art proteomic methods of protein detection and post-translational modification
quantification will serve to greatly enhance the value of this core to the DRC investigator community. Together,
these two sub-cores provide DRC members with the unique opportunity to systematically address pertinent
mechanistic questions in vivo and to assess metabolic changes in both the central nervous system and
peripheral tissues in the most efficient and economical manner.

## Key facts

- **NIH application ID:** 9898362
- **Project number:** 5P30DK045735-28
- **Recipient organization:** YALE UNIVERSITY
- **Principal Investigator:** Raimund Ingo Herzog
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $248,839
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9898362

## Citation

> US National Institutes of Health, RePORTER application 9898362, Physiology Core (5P30DK045735-28). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9898362. Licensed CC0.

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