# Autonomic Determinants of Postural Tachycardia Syndrome

> **NIH NIH R01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $423,331

## Abstract

Abstract
Postural tachycardia syndrome (POTS) is a relatively common condition affecting mostly otherwise healthy
young women. It is the cause of significant disability and an impairment in quality of life of a magnitude
comparable to patients with chronic obstructive pulmonary disease or congestive heart failure but the underlying
pathophysiology is heterogeneous. In most patients sympathetic activation is likely an appropriate compensatory
response to deconditioning, partial neuropathy or hypovolemia. Our preliminary studies, however, show that a
very high salt diet administered under controlled conditions in a metabolic unit does not resolve the volume
deficits or sympathetic activation in POTS patients. On the other hand, we have identified a subset of patients
with high resting supine central sympathetic outflow, as determined by muscle sympathetic nerve activity (MSNA)
above the upper 95% confidence interval for the group. This “primary sympathetic” (psPOTS) subset is
associated with a paradoxical increase in upright blood pressure and pressor responses to Valsalva, and appear
to improve clinically on central sympatholytics. Thus, our overarching hypothesis is that there is a subset of
POTS patients with a central sympathetic activation as the primary pathophysiology. We propose to test
this hypothesis in a double blind, placebo-controlled, randomized study using the central sympatholytic
moxonidine. If our hypothesis is true, sympathetic inhibition will improve orthostatic symptoms (Specific Aim 1),
blood volume (Specific Aim 2). We would expect worsening of all these parameters if sympathetic activation is
compensatory in nature. Moxonidine was selected for this proof-of-concept study because it is an effective
sympatholytic imidazoline agonist that has less sedative effect compared to older agents. We will also determine
if a high salt diet will be a more effective treatment for POTS in the presence of moxnidine. In Specific Aim 3, we
propose a complementary approach to determine the central processing gain and peripheral effector gain of
sympathetic outflow, by closed loop identification techniques using randomized neck suction and wavelet
decomposition to extract individual spikes from sympathetic neurograms. We hypothesize that the central arc
gain is higher in psPOTS and can be normalized by sympatholysis with moxonidine. We will also perform a
secondary analysis using a logistic model to regress each patient's psPOTS status, as determined by
microneurography, against clinical variables, to identify readilly accessible characteristics that can be used
clinically to identify hyperadrenergic POTS. We believe the proposed studies will advance this field and ultimately
help our patients by improving our current phenotyping capabilities and developing new therapeutic targets.
studies will advance this field and ultimately help our patients.

## Key facts

- **NIH application ID:** 9898448
- **Project number:** 5R01HL142583-02
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Andre Diedrich
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $423,331
- **Award type:** 5
- **Project period:** 2019-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9898448

## Citation

> US National Institutes of Health, RePORTER application 9898448, Autonomic Determinants of Postural Tachycardia Syndrome (5R01HL142583-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9898448. Licensed CC0.

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