# Plasma Metabolomics and Myocardial Energetics in Heart Failure

> **NIH NIH R01** · HENRY FORD HEALTH SYSTEM · 2020 · $763,273

## Abstract

ABSTRACT
 Heart failure (HF) remains an enormous public health problem despite advances in treatment. Disease
progression and response to therapy in HF varies widely between individuals, but breakthrough technologies
such as genomics and metabolomics are helping to unravel the disease heterogeneity that confounds patient
management. Perturbed energy metabolism may be a key contributor to cardiac dysfunction and the
development of clinical HF. Evidence from a variety of sources indicates that impaired structure and function
of the energetic apparatus in the myocardium contributes to disease severity, progression, and may influence
response to treatment. However, in order to advance these observations toward meaningful interventions for
HF patients, several key steps are still needed: 1) confirming the importance of metabolic variation in human
HF, 2) developing noninvasive markers of myocardial energetic status, and 3) identifying promising targets for
intervention. Our proposed project is a series of interwoven translational investigations in humans and dogs
with HF to define the association of plasma metabolite levels with disease severity, myocardial energetics, and
disease progression. This project leverages substantial infrastructure already in place a large existing genetic
cohort study, available plasma samples suitable for metabolomic profiling, comprehensive translational
laboratory capabilities, and a cohesive multidisciplinary research group focused on HF. Together the planned
studies will address the overarching hypothesis that the peripheral metabolomic signature can indicate disease
progression/treatment responsiveness in HF patients and that this is driven by altered myocardial energy
metabolism. If true, then these data will help advance personalized therapy and identify novel targets for HF
intervention, leading to improved outcomes for HF patients.

## Key facts

- **NIH application ID:** 9900043
- **Project number:** 5R01HL132154-04
- **Recipient organization:** HENRY FORD HEALTH SYSTEM
- **Principal Investigator:** David E Lanfear
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $763,273
- **Award type:** 5
- **Project period:** 2017-04-15 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9900043

## Citation

> US National Institutes of Health, RePORTER application 9900043, Plasma Metabolomics and Myocardial Energetics in Heart Failure (5R01HL132154-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9900043. Licensed CC0.

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