# Core D: Pilot Project Core

> **NIH NIH P50** · CLEVELAND CLINIC LERNER COM-CWRU · 2020 · $129,849

## Abstract

ABSTRACT 
The overall goal of the Northeast Ohio Alcohol Center (NOAC) is to identify specific molecular targets 
responsible for ethanol-induced tissue damage, as well as to understand the complex adaptive and 
maladaptive responses of cells and systems to that damage. This information will enable us to 1) target 
therapeutic interventions to slow and/or reverse the progression of alcohol-induced tissue injury and 2) develop 
specific assays that can assess the efficacy of novel therapeutic strategies in relevant clinical populations. The 
NOAC brings together an outstanding team of interdisciplinary investigators including geneticists, cell 
biologists, oxidation biochemists, biomarker experts, synthetic chemists and clinical translational investigators. 
A critical element to leveraging the expertise of our team of investigators is to provide support for pilot projects. 
Pilot projects bring innovative and promising new approaches to the alcohol field and facilitate collaborations 
between team members and outside investigators to build onto their existing individual research programs. 
Pilot projects are supported by our Animal and Cell Models Core and Clinical Core, facilitating rapid progress 
for investigators new to the area of alcohol research. Importantly, the supportive intellectual environment with 
broad expertise in biomedical and clinical investigations will allow for the continued development of novel and 
innovative pilot projects. Therefore, support for pilot projects will likely have a large impact on the progress of 
research on mechanisms and treatments for ethanol-induced tissue injury. The Specific Aims of the Pilot 
Projects Core are to 1) Advertise the availability of Pilot Projects and invite pilot projects from faculty at 
Cleveland Clinic, Case Western Reserve University, Northeast Ohio College of Medicine and National 
Children’s Hospital, organize their review and ranking, 2) Provide support for junior investigators in 
implementing their proposals and 3)Monitor progress of Pilot Projects on a yearly basis. Implementation of the 
Pilot Projects Core will allow for funding of novel and innovative hypotheses with a rapid turnaround from 
conceptualization to actualization, facilitate collaborations between basic and clinical investigators and provide 
seed money to test exciting new approaches to understanding pathophysiology of ethanol-induced tissue 
injury, as well as development of biomarkers for disease progression and susceptibility. Importantly, the Pilot 
Projects Core will also extend the numbers of participating investigators in the NOAC and continue to build a 
community able and willing to conduct cutting edge basic and clinical alcohol-related research.

## Key facts

- **NIH application ID:** 9900706
- **Project number:** 5P50AA024333-05
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Thomas M McIntyre
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $129,849
- **Award type:** 5
- **Project period:** — → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9900706

## Citation

> US National Institutes of Health, RePORTER application 9900706, Core D: Pilot Project Core (5P50AA024333-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9900706. Licensed CC0.

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