Admin Core Project Summary We propose to establish the Arizona Cancer and Evolution Center (ACE). Arizona State University will lead the Arizona Cancer and Evolution Center effort. Drs. Maley and Shibata, co-principal investigators, will direct the Center in collaboration with NCI program staff. ACE integrates a team of modelers, evolutionary biologists and cancer biologists with a successful track-record of collaborations. The objective of the Arizona Cancer and Evolution Center Administrative Core is to provide the necessary infrastructure for the overall organization and effective management of the Center to achieve the objectives of the CSBC and the NCI, as well as realize the scientific goals of the Center. The ACE Administrative Core will accomplish four Specific Aims during this funding period: Aim 1 Create and maintain a knowledgeable, skilled, and interdisciplinary leadership team that is connected to the research and the wider network; Aim 2 Design and implement a clear and effective communication plan across the Center; Aim 3 Identify and foster pilot projects; Aim 4 Solicit, coordinate, and respond to external advice for the scientific direction and opportunities for ACE. IMPACT: The Administrative Core will enable the Arizona Cancer and Evolution Center to transform current understanding and management of cancer by developing the theory, models, and measures of cancer that will be applicable and clinically relevant across cancers and species.