# Bioanalytics Core

> **NIH NIH P01** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $103,545

## Abstract

Summary
 The Bioanalytics Core (BC) will support the implementation of a uniform, innovative approach to the
analyses of the Program's research Projects. The Core consists of Dr. Timothy Houle and Carol
Aschenbrenner, both of whom are experienced biostatisticians with expertise in the proposed methods. The
goals of the BC are to evaluate the statistical inferences posed in each of the Projects using the most
appropriate statistical model. To accomplish these goals we will utilize several approaches including: growth
curve modeling, generalized linear models, generalized estimating equations and other multivariate procedures
(e.g., multidimensional scaling). The BC will work closely with the individual investigators of the Projects (PIs:
Peters, Martin, Eisenach) to condition the data and address the specific hypotheses inherent in the research.
All of the Projects involve studies that repeatedly measure some element of recovery over time after a
surgical/experimental insult. Growth curve modeling, sometimes referred to as mixed-effects modeling, or
hierarchical linear modeling, will allow us to specify a change trajectory (i.e., healing) that is unique to each
individual/animal. The nature of the common form of changes in pain/behavior will be modeled using
curvilinear forms (e.g., polynomial regression). Through the use of fixed and random effects, we will then be
able to examine the influences on the changes in pain measurements in both the human and animal studies. In
this way, we can examine the predictors immediately after surgery, the factors that predict delayed/absent
recovery, patterns in these changes across individuals, and examine the relationships between initial
measurements and expected change. This approach to the data analysis is highly innovative in this setting,
and will extract novel information from these important data.

## Key facts

- **NIH application ID:** 9900811
- **Project number:** 5P01GM113852-05
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** TIMOTHY T HOULE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $103,545
- **Award type:** 5
- **Project period:** — → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9900811

## Citation

> US National Institutes of Health, RePORTER application 9900811, Bioanalytics Core (5P01GM113852-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9900811. Licensed CC0.

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