# Senescence-Chips for Radiation Biodosimetry

> **NIH NIH R44** · NEWOMICS, INC · 2020 · $997,365

## Abstract

Ideal biomarkers for acute and delayed radiation injury after a radiological/nuclear terrorist incident are those
that arise and are measurable prior to manifestation of tissue injuries, typically one to a few days after ionizing
radiation (IR) exposure. However, there are currently no commercial platforms that could perform assays for
these biomarkers with high robustness, sensitivity, and specificity for radiation biodosimetry. In response to PA-
18-525, Newomics Inc. proposes in this Phase II project to complete development of its product, termed
“Senescence-Chips”, for rapid and accurate detection of senescent cells, particularly, IR-induced senescent
cells, for radiation biodosimetry and medical countermeasure. The Phase II project is built upon the promising
results generated from our Phase I project. In Phase I, we have developed the integrated microfluidic chips, and
demonstrated their proof-of-principle applications for ultrahigh-throughput isolation and removal of senescent
cells spiked in whole blood. In Phase II, we will complete development of the senescence-chips for
commercialization, and develop new multiomics assays for analyzing molecular marker panels using Newomics'
breakthrough multinozzle emitter array chips. Once developed, Newomics' integrated platforms and solutions
will enable low-cost, reproducible, highly specific and sensitive multiplex measurements of human peripheral
blood for radiation biodosimetry, thus serving as a field-deployable platform for radiological/nuclear medical
countermeasures including emergency triage and medical responses.

## Key facts

- **NIH application ID:** 9901427
- **Project number:** 5R44AI106100-04
- **Recipient organization:** NEWOMICS, INC
- **Principal Investigator:** DAOJING WANG
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $997,365
- **Award type:** 5
- **Project period:** 2014-08-05 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9901427

## Citation

> US National Institutes of Health, RePORTER application 9901427, Senescence-Chips for Radiation Biodosimetry (5R44AI106100-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9901427. Licensed CC0.

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