# Human phenotype (Core A)

> **NIH NIH P30** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $293,375

## Abstract

Human Phenotyping Core 
PROJECT SUMMARY/ABSTRACT 
Studies of the molecular physiology and genetics of body weight regulation are increasingly dependent upon 
highly sensitive and accurate measurements of energy expenditure, body composition, adipose tissue biology, 
ingestive behaviors and brain imaging, as are the analyses of prophylactic and therapeutic interventions. 
Hence, the current Human Phenotyping Core (HPC) and affiliated laboratories are critical resources in the 
NYONRC's (and NIH's) commitment to advance understanding of the pathogenesis of obesity. The combined 
HPC resources are unique to the NYONRC, and the laboratories attract students and visiting scientists at all 
levels from around the world. The use of the HPC laboratory by Members/Users continues to grow. The HPC 
has provided consultative advice to investigators on phenotypes to be measured and the interpretation of these 
tests. The HPC has a large training function and is therefore highly responsive to the needs of Members and 
allows for greater productivity at lesser cost for them. The Research Base includes a large group of federally 
funded investigators who require the methodologies offered in the HPC to conduct their studies. The facilities 
and services provided by this Core are unique and not available commercially or to the individual Core users 
(reasons include too costly, too labor-intensive, or too specialized). During this current cycle, 18 investigators 
with support from 18 NIH grants that included 3 NYONRC Pilot & Feasibility awards submitted 9000 Core 
service requests, which were met, contributing to 108 peer-reviewed publications and the generation of 21 
grant applications (14 funded and 7 pending). The overall objective of the HPC is to enhance and expand the 
research capabilities of investigators performing clinical and translational studies in humans related to obesity 
and eating disorders and their related physiological/medical phenotypes. The Specific Aims of the HPC are 
to: 1) Make available to Center members specialized measurements in body composition, energy expenditure, 
imaging & analysis, and adipose tissue analysis in human subjects; 2) Provide investigators with 
consultation/advice in determining which methods or combination of methods are best suited to their needs 
based on the scientific questions in the context of budgetary constraints; 3) Provide a setting in which 
instruction in these technologies and strategies can be provided to students, postdoctoral research fellows, and 
interested scientists; 4) Sponsor and participate in the conduct of periodic seminars on "state-of-the-art" body 
composition, energy expenditure, sleep physiology, imaging analysis, adipose tissue analysis, with ultimate 
emphasis on those aspects of greatest relevance to the problem of human obesity; 5) Provide reduced-cost 
access to these technologies to NYONRC Pilot and Feasibility recipients and post-doctoral fellows; 6) 
Advance/develop non-invas...

## Key facts

- **NIH application ID:** 9901509
- **Project number:** 5P30DK026687-40
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** DYMPNA GALLAGHER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $293,375
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9901509

## Citation

> US National Institutes of Health, RePORTER application 9901509, Human phenotype (Core A) (5P30DK026687-40). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9901509. Licensed CC0.

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