# Animal Phenotyping (Core B)

> **NIH NIH P30** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $254,563

## Abstract

Animal Phenotyping Core 
PROJECT SUMMARY/ABSTRACT 
Rodent models of obesity have provide invaluable to the study of obesity and to the work carried out by 
NYONRC investigators. To meet the growing needs of Center researchers, the proposed NYONRC Animal 
Phenotyping Core (APC) reflects a significant expansion of the Animal Energy Balance Core (Einstein) and 
integration with the animal component of the Adipose Tissue Core (Columbia). During the past 4 years of the 
current cycle, these components of the NYONRC have processed more than 14,000 service requests for 38 
NYONRC members supported by 45 grants, and provided additional services to 9 NIH-funded non-NYONRC 
members. The services offered by the APC have been instrumental in obtaining 19 new or renewed grants, 
and in the generation of 213 publications. The proposed APC concentrates and coordinates significantly 
expanded technical and research capabilities of this amalgamated Core. The incorporation of additional animal 
resources at both the Einstein and Columbia campuses, will significantly increase the user and research base 
of the NYONRC overall, and of the APC Core in particular. By coordinated application of NYONRC dedicated 
facilities, and resources and expertise at both Columbia and Einstein, the proposed APC Core will combine 
sophisticated qualitative and quantitative measurements of ingestive behavior with concurrent assessments of 
energy expenditure, physical activity, body temperature, and repeatable noninvasive body composition 
analysis by MRI and MicroCT. Also available are a range of metabolic surgeries, including gastrointestinal 
bypass, autonomic denervation procedures, and adipose tissue services including: 1) quantifying adipocyte 
subpopulations (brown, white, beige), in terms of size, variation, and cellular ultrastructure; 2) primary cell 
isolation and analysis; 3) differentiation of adipocytes and adipose tissue macrophages; and 4) adipose tissue 
transplantation. This expanded array of services stems from the growing realization that our understanding of 
the biology of obesity requires simultaneous assessment of energy intake and energy expenditure, and of the 
means to determine their net effects on energy balance repeatedly in individual animals. 
The Specific Aims of the APC are to provide state-of-the-art assessments of: 1) Adipose Tissue 
Morphology & Function, in terms of cellular, histologic and functional analyses; 2) Body Composition, in 
terms of the total relative fat and lean mass, and whole body anatomical distribution of adipose tissue; 3) 
Energy intake and Expenditure, including oxygen and CO2 consumption, respiratory quotient, and 
thermogenesis in brown adipose tissue; and 4) consequences of Metabolic Procedures and Surgeries, 
designed to illuminate the physiology of weight regulation and obesity pathophysiology, including 
gastrointestinal bypass, autonomic denervations and central nervous system targeting using viral, optogenetic 
and che...

## Key facts

- **NIH application ID:** 9901511
- **Project number:** 5P30DK026687-40
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** GARY J SCHWARTZ
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $254,563
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9901511

## Citation

> US National Institutes of Health, RePORTER application 9901511, Animal Phenotyping (Core B) (5P30DK026687-40). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9901511. Licensed CC0.

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