# Mouse Genome Database

> **NIH NIH U41** · JACKSON LABORATORY · 2020 · $3,658,940

## Abstract

PROJECT SUMMARY – OVERALL COMPONENT
As the cost of genome-scale sequencing continues to decrease and new technologies for genome editing
become widely adopted, the laboratory mouse is more important than ever as a model system for
understanding the biological significance of human genetic variation and for advancing the emergence of
genomic medicine. The Mouse Genome Database (MGD) has a unique and strategic role as a community
resource for facilitating the use of the laboratory mouse for understanding human biology and disease. MGD
serves three major user communities: (i) biomedical researchers using mouse experimentation to investigate
genetic and molecular principles of biology and disease processes, (ii) clinical and translational scientists using
mouse as a model to study human disease, and (iii) bioinformaticians / computational biologists using the rich
integrated data in MGD to develop algorithms and bioinformatics pipelines for data analysis and interpretation.
In the grant renewal period, MGD staff will continue to integrate new genetic, genomic, variant, functional,
phenotypic, and human disease model data essential to researchers using the laboratory mouse in biomedical
research. We will make these data freely available through a variety of web-based and programmatic user
interfaces. Our Resource Project aims include (i) maintaining the canonical catalog of mouse genome features,
(ii) serving as the authoritative data for mouse functional annotations, and (iii) maintaining a comprehensive
catalog of mouse mutant alleles and their phenotype and disease model associations. We also will expand and
refine our Human-Mouse Disease Connection portal to serve the clinical, translational, and comparative
research communities.
To support our Resource Project aims, we will maintain cost-effective software, database, and hardware using
industry best practices. We will maintain MGD's secure infrastructure through regular maintenance, upgrades,
and planned evolution. We will develop new software components to accomplish biologically driven initiatives
and we will implement enhancements to the system as new data types and data sources relevant to our
mission emerge.
To ensure the greatest impact of MGD in the broader scientific community, we provide robust user support and
outreach through online user documentation, tutorials, training workshops, and one-on-one assistance using a
variety of communication modalities and major social media tools. We actively solicit community input, data
submissions, and collaborations.

## Key facts

- **NIH application ID:** 9901544
- **Project number:** 5U41HG000330-32
- **Recipient organization:** JACKSON LABORATORY
- **Principal Investigator:** CAROL J BULT
- **Activity code:** U41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $3,658,940
- **Award type:** 5
- **Project period:** 1997-07-01 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9901544

## Citation

> US National Institutes of Health, RePORTER application 9901544, Mouse Genome Database (5U41HG000330-32). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9901544. Licensed CC0.

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