# Cell, Tissue and Animal Core

> **NIH NIH P30** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2020 · $258,433

## Abstract

Cell-Tissue-Animal Core
Abstract
The primary objective of this core is providing primary cell culture and animal models to CHAIN
investigators to execute their research projects on the effect of chronic HIV infection/ aging/ cART on
brain disease. We have long provided quality primary cells from rodents and humans for Center
investigator use. We have newly developed Humanized NSG mouse model and have experience in
other rodent models of neuroAIDS. We have multiple techniques and assays enabling the study of
both rodent and nonhuman primate models, valuable tools to ask CHAIN and related research
questions. The cells and models provided and supported by this Core are essential in many our
investigators’ neuroAIDS studies. By employing Imaging and Omics Cores, investigators can study
progression of disease and molecular determinants of neuropathology in animal models. State of the
art methods of analyses are also provided. The general goals of this core is 1) to support the center
investigators by providing primary human and rodent blood and brain cells and tissues from animal
models of neuroAIDS; 2) to work with CHAIN investigators in the study of animal models of chronic
HIV CNS infection, and 3) to provide services/training in situ brain tissue analyses, quantification for
SIV/HIV viral RNA, DNA loads, and many other immunological and virological assays required to
study CNS disorders.

## Key facts

- **NIH application ID:** 9901612
- **Project number:** 5P30MH062261-19
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** Santhi Gorantla
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $258,433
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9901612

## Citation

> US National Institutes of Health, RePORTER application 9901612, Cell, Tissue and Animal Core (5P30MH062261-19). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9901612. Licensed CC0.

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