# Role of Notch pathway in kidney injury

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $578,663

## Abstract

Fibrosis is the histological manifestation of chronic kidney disease (CKD). While the
kidney can fully regenerate and repair following acute kidney injury (AKI), injury
response can also follow a maladapative path in fibrosis resulting in epithelial atrophy,
accumulation of myofibroblasts, collagen and inflammatory cells.
A key bottleneck to progress in our understanding of regeneration and differentiation has
been the limited insight into cell-specific genome wide gene expression changes. A
revolution in cellular measurement technology is under way. For the first time, we have
the ability to monitor genome-wide gene regulation in thousands of individual cells in a
single experiment, using single cell “omic” studies. Such experiments allow us to
discover new cell types and states, trace the origin of cells and identify underlying cell-
specific gene expression changes therefore, this method shall enable us to understand
reparative and maladaptive regeneration in fibrosis.
The primary goal of this proposal is to explore the hypothesis that the Notch pathway
plays an important role in the development of chronic kidney disease and kidney fibrosis.

## Key facts

- **NIH application ID:** 9902385
- **Project number:** 5R01DK076077-12
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** KATALIN SUSZTAK
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $578,663
- **Award type:** 5
- **Project period:** 2006-07-01 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9902385

## Citation

> US National Institutes of Health, RePORTER application 9902385, Role of Notch pathway in kidney injury (5R01DK076077-12). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9902385. Licensed CC0.

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